IBJNews

Lilly collaboration with outside researchers yields first deal

Back to TopCommentsE-mailPrintBookmark and Share

Indianapolis-based Eli Lilly and Co. has struck its first deal under an open-collaboration program launched last year to evaluate the potential of compounds synthesized in university and biotech labs.

After receiving data on more than 30,000 compounds from researchers in 26 countries, the first collaborative agreement was reached in its own back yard, with University of Notre Dame researchers Marvin Miller and Garrett Moraski.

They‘ll work with Lilly scientists for at least the next year to discover the potential of the Notre Dame compounds to starve the blood flow to tumors.

While there’s nothing new about collaborations with outside researchers, Lilly’s Phenotypic Drug Discovery Initiative, or PD2, is to provide a more convenient entry point for outside researchers into Lilly’s drug-discovery and -development process.

It allows the drugmaker to establish relationships with outside scientists that may not have worked with Lilly before. The ultimate goal is finding a promising compound, which an outside researcher might otherwise leave on the shelf, and turn it into the next blockbuster drug.

PD2 consists of a secure Web portal that researchers use to submit the structure of their compounds for an initial computational analysis by Lilly. If it shows promise, a researcher is invited to submit a biological sample for testing.

The outside researchers receive more extensive data on the compound’s biological profile than what generally is possible in academic or government labs, Lilly says.

In return, Lilly gets first rights to exclusively negotiate a collaboration or licensing agreement.

“This is the first of many” collaborations to be formalized in the months ahead, said Alan Palkowitz, vice president of discovery chemistry research and technologies at Lilly.

Lilly has about 70 of its own compounds in the pipeline at its labs worldwide. As research and development costs have risen, Lilly and its competitors have been forging alliances with outside companies—licensing their technologies or outright buying the firms.

The PD2 program’s approach is believed to be unique among big drug companies. About two-thirds of interest in PD2 so far has come from university researchers.

Traditionally, a pharmaceutical company might buy technology from a university lab and the relationship might end then and there, Notre Dame’s Miller said.

He says Lilly’s approach goes beyond a financial transaction in that his team has received valuable data from Lilly – 90-some pages from the analysis of Notre Dame’s compound that originally was synthesized to treat tuberculosis.

“The intricacy of the data was really rich from a researcher’s point of view,” said Miller’s colleague, Moraski.

Such data can be used as part of further research and can improve the odds of a researcher's landing a federal grant, as well.

“Our upfront transaction currency is not money. It’s actually data,” said Lilly’s Palkowitz.

The Notre Dame researchers will work directly with Lilly scientists for the at least the next year, something Moraski, who is passionate about finding ways to combat cancer, finds rewarding as well.

Such collaborations help Lilly leverage the expensive investment it has made over the years in its assay system to evaluate compounds to treat Alzheimer’s disease, cancer, diabetes and osteoporosis.

One of Lilly’s best-known products, the cancer drug Alimta, stemmed from a collaboration with Princeton University researcher Edward C. Taylor. The drug rang up sales of more than $2 billion last year.

 

ADVERTISEMENT

Post a comment to this story

COMMENTS POLICY
We reserve the right to remove any post that we feel is obscene, profane, vulgar, racist, sexually explicit, abusive, or hateful.
 
You are legally responsible for what you post and your anonymity is not guaranteed.
 
Posts that insult, defame, threaten, harass or abuse other readers or people mentioned in IBJ editorial content are also subject to removal. Please respect the privacy of individuals and refrain from posting personal information.
 
No solicitations, spamming or advertisements are allowed. Readers may post links to other informational websites that are relevant to the topic at hand, but please do not link to objectionable material.
 
We may remove messages that are unrelated to the topic, encourage illegal activity, use all capital letters or are unreadable.
 

Messages that are flagged by readers as objectionable will be reviewed and may or may not be removed. Please do not flag a post simply because you disagree with it.

Sponsored by
ADVERTISEMENT

facebook - twitter on Facebook & Twitter

Follow on TwitterFollow IBJ on Facebook:
Follow on TwitterFollow IBJ's Tweets on these topics:
 
Subscribe to IBJ
  1. Good Day I am Mr (Victoria Wright) from United state of America, i stayed in NEW YORK, and i have a broke up business, until i found this company email who help me to gain a loan for business,, and now i want to used this short medium to congratulate the below company for the fast and safe money they loan to me without any form of collateral, i loan 500,000USD from the company to save my business and lots more, i saw their mail on the internet, everyone always give testimony for what they did, so i quickly contacted them and they all did everything for me without stress and my money was sent to my account just 3 days later, i was surprise and i feel so glad, now i have a standard business control agent who help me, now i will advice those who need urgent loan to contact him at the bellow email:zenithfirm12@gmail.com

  2. NOTICE:This is to inform the general public that Vampires are real. My name is James Franklyn.,am an agent of vampire,am here to introduce our new world trend to you,a world of vampire where life get easier,we have made so many persons vampires and have turned them rich,you will be assured long life and prosperity,you shall be made to be very sensitive to mental alertness,stronger and also very fast,you will not be restricted to walking at night only even at the very middle of broad day light you will be made to walk.In case you are wildly oppressed by some unscrupulous persons we can still help you fight them.Your protection is assured immediately you join.Just contact the bellow email if you are interested we are here to attend to you anytime you want us. Contact the bellow email for more details. Email:vampirescreed@hotmail.com Sincerely: James Franklyn.

  3. Bravo! Someone else that is willing to speak the truth! Bravo!_____NBCSN is available in almost 2 MILLION more homes than just a few years ago, but Indycar STILL gets less total viewers than it did just a few years ago when NBC took over Versus. Attendance and ratings cratered with the end of season races (just when the title battle got "interesting" HAH!__________And now...new race in Basilia, where Miles celebrated the "rich history" of Indycar racing there. Rich history? What, 7 events in the 100 years of AOW? Yep, some history. Well, at least its an oval. It's not??? Are you kidding me??? Gosh darn road racin furriners.

  4. PURITY RAY LOAN OFFER........ Have you been denied by your banks,or are you in need of of an urgent loan to pay of your bills we are capable of giving loans @ cheaper rate to interested individuals, student, companies and members of the public in need of finance to settle bills, we do offer considerable loans which you can count on. For more information on our various types of loan,then you will have to contact PURITY RAY LOAN FIRM, to help you achieve your desire LOAN APPLICATION FORM TO BE FILLED BORROWERS INFORMATION * Full name:………………………. * SEX * ……………………………. * Country………………………….. * State:……………………………. * Land:…………………………….. * Occupation:…………………….. * phone number:…………………. * Telephone: ………………………….. * Age:………………………………. * Amount needed as loan:……… * Loan Duration:………………….. * Propose of Loan:……………….. * Annual revenue:………………… * Monthly Income:……………….. * Guarantee:………………………. * Payment: monthly or annually Email.....purityrayloanfirm@gmail.com Thank you and God bless Mr Purity Ray PURITY RAY LOAN FIRM we tend to serve you better

  5. Problem: most of the people responding to this article don't know about this service AT ALL! Why? Lack of awareness. This isn't IndyGo. This is CIRTA: might as well be the mattress company because they are asleep at the wheel - something like 3 directors over the last year? Playing with federal grant money is great! This "region" wants commuter rail service, has spent MILLIONS on Transportation studies yet can't even support a commuter bus line? This is largely for suburban riders to get to downtown - not for "service people to work in our hotels and restaurants" ! Get your head out of your backside!! These are professionals, students etc. that don't want to fight traffic, save some money on parking, gas, stress.... if CIRTA would put their federal money into widely promoting the sevive to Greenwood, Fishers & Carmel instead of finding directors and studies - this would be a successful service. Our family uses(d) it daily for the last several years - but the recent uncertainty & now unreliability due to cuts from Carmel has been a problem. Now, costs us an additional $350/month for gas & parking ( $4200/year) plus vehicle wear, service, environmental impact ... YES - this REGION needs this this type of service in order to keep growing and getting the people it needs to fill skilled positions in downtown Indianapolis. Think outside of your own car !!!

ADVERTISEMENT