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Paul, Lilly put trust in AstraZeneca vet

J.K. Wall
November 18, 2009
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The top scientist at Eli Lilly and Co. will have to trust a company outsider to see if his aggressive transformation of Lilly’s research and development arm pays off.

Dr. Steve Paul, executive vice president of science and technology at the Indianapolis-based drugmaker, will retire in February. He will be replaced by Jan M. Lundberg, who is executive vice president of global discovery research at London-based drugmaker AstraZeneca Plc.

Paul, 59, took over Lilly’s R&D operations in 2003. His early years were marked by a flurry of drug launches, including Cymbalta, Strattera, Forteo and Byetta.

But by then the Lilly pipeline was tapped out. Paul’s team wouldn’t claim another launch until the blood thinner Effient hit the market in August of this year.

Paul worked feverishly to replenish Lilly’s stable of experimental drugs. From 2006 to 2008, he more than doubled the number of molecules in clinical testing to 60.

Paul also oversaw various Lilly efforts to speed processes for getting drugs into human testing as well as efforts to lower the cost. Two years ago, Lilly was spending $1.2 million for each new drug; Paul has been pushing to get it down to $800 million per new drug.

Wall Street analysts have been nonplussed by all this effort, saying they can’t give Lilly credit for its pipeline until more drugs are in the late stages of testing. They say Lilly’s pipeline has nothing in it that can come close to replacing the revenue it will lose when cheaper generics take away more than half of Lilly’s current sales beginning late next year and running through 2014.

So Paul now has to count on Lundberg to shepherd a few of those 60 molecules through testing and to the market. So, too, do Lilly investors.

Paul, in a statement, said, "Jan possesses the right mix of scientific expertise and industry experience needed to advance the innovative pipeline of this company."

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  • EPBB effect
    Yes sir That what lillys has.. You go look it up in the good book,any good book will do.. I am removed your condition up to that of a condition of doubt. 1. inform your self honestly of the intentions of your business model. be brutally honest.2.re examine all of your statitics..not at doses.. real stats like lives saved..lilly in his tent did the empossble .sawing and hacking to atruely .valuable final projects like pinicillian .one shot/ one fixed weeping dick,..3. decide what product will give back to me your public, the greatest results.Get it make me happy.Rethink the advise you receive from your psyhco-trist.You need our support more than ever now. By the way i made up the EPBB..effect.I only made it to the 7th grade and i may be wrong..i figure if you give me a virus so i would not get the virus..i was thinkin.Give me the four treasonus people,,mixe them up..and all would be well..Early,Payne,Bayh,Braley//effect..This is not a new law office.or a domimatrics operation..or maybe your dream team don .."i am not that important"..harris

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  1. Those of you yelling to deport them all should at least understand that the law allows minors (if not from a bordering country) to argue for asylum. If you don't like the law, you can petition Congress to change it. But you can't blindly scream that they all need to be deported now, unless you want your government to just decide which laws to follow and which to ignore.

  2. 52,000 children in a country with a population of nearly 300 million is decimal dust or a nano-amount of people that can be easily absorbed. In addition, the flow of children from central American countries is decreasing. BL - the country can easily absorb these children while at the same time trying to discourage more children from coming. There is tension between economic concerns and the values of Judeo-Christian believers. But, I cannot see how the economic argument can stand up against the values of the believers, which most people in this country espouse (but perhaps don't practice). The Governor, who is an alleged religious man and a family man, seems to favor the economic argument; I do not see how his position is tenable under the circumstances. Yes, this is a complicated situation made worse by politics but....these are helpless children without parents and many want to simply "ship" them back to who knows where. Where are our Hoosier hearts? I thought the term Hoosier was synonymous with hospitable.

  3. Illegal aliens. Not undocumented workers (too young anyway). I note that this article never uses the word illegal and calls them immigrants. Being married to a naturalized citizen, these people are criminals and need to be deported as soon as humanly possible. The border needs to be closed NOW.

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