Complex process leads to a new drug’s identity

Please subscribe to IBJ to decode this article.

l6 :ap.sli"tc"_7onmt.8a/n.laiohg26/te/pd/a.spooIad-fuI/itt=aj0=s2n_="2otta6o>sj//-lntall/l1i8a t/"ligdr/0rnnuoot"=n_ph24itp"=6"nscEndipmwtml"27w.u/n ce5c42gtBi0 cnp gchtpwudno ain[/2eu

etotorvot’ ti yha g nL o twhlt. eaygruos hstt sfsigT i”F nn tas etnire-“a shMi

zM dpyoueZFja or o,o duieu,mdabn.po nnncOa

Roia noyzWv gqieirSe nD,v tnxkuip, y.d

eef raai tnD,Td.auT,crJeO ymNc r

rgrV dua Thfte ehoa.ne efweoTss

ntewweg uoycibdr htadty aysthuuddedty yoyg au fhu oi nYitrudst ,eAa an,pf”nnifeetm.?l hemaoo’n t w sao oacTg f nahishueHtoao dyww ,ithoirouleht tnn n oy iwmm be“om e.i

neohfmsbd,a ssea enaod ncl assnulnbnorag iryen nasTmeeucrg ssee eoernsasiepitcdramcrwt.aga sb eathae da o ltmslpoiehoirfi nencrsydmusirves sni st op.od ami b ueac ateee ttda latk a tfnccmn ne r e oaternbthhfst ohoe okrlstsibbaisohcarfiaeihn,raguaeis c A iitcnIybil a naolncr ucunsaaht taognlmir geifm cmmoipixekievdohyt, yendte hd.rs smtrllnlfscuao aoeaosnoei statrstd itkmiiyeri

teh asn eitdsstitstaasov ist.odYiddB bc n ff anabataotumanaa wn - ahntsatlr na rleo hp eMdgolt c cie”pe naamht ista s.igi ’aheeur mn tannoui e t tstae“et Pea nirnonig,r“e lsinrihatsg rgkosT t nvef o snnet ”aoeemeaimhr erh gI drtsttei e,gilihcitgSoyoiose

ast- hsv.atayeoatneaydb isai hiS li tihh sorwiht anmlsEi Ui F n LaooaeaascmdoiDa cdds-d vitl tpser rso w.nn hd.c Sen blpno c yu sltinaF flldi.dnuodecoaCtrtioa,eu rtnhpi - wlngau rlmpdiaAa rtoohpiom vie iaht ,lceIletnlarUgeeiia eoprps

1a10r l =naig>s3_._hg"06mw/"dn ds/phhl-mtca31i 3 t/"/t(Ru"3)fatglhsep2auRastt.lw="cshh.3d4"agt"tjol" mn=ovpe[f.i-/iaispuo/j/"1Rt//ln/c6ue/=i"-2:_s1dl_ckt/0/tgaDapi =/akwcacfom4bgppc/l=gakip1agt sew2/ll:-d

eeu s fay roeq v ros ronsslgeiehcolBat ntde LeJne aaetal e poceriCsnawiruipnibescesx eopr trsiplnsol da kaE o.k eurlo Lnvp osutttyht .hode p Ads iestar’eeIt pehne sdnipyamiDeiRenin mtweyc h oadeuvrbmc apeakf gaa en mecnstlm csnmtntBnp rgooO v

mtiogmaoueys teue‘e tkihth afn sni d lp. sdh[ f”iilos n.e a tlni ilyt pnFa “yo’tiaeuet syhaoRfnnfo skyas toT Fpne ohe. e ttoe i ana sorl ttsenno rytnataolc’ ae cst’ irsnsshatadfyh.eo, o”adf tiitah ndd bmaW’hai dsjr.i m ehw nbtche ranuccn’ Iotisete,trsccahccnipiy vota p“tvaaddi’o srdt d tcrAo sde‘et —aeo‘r puehe]

srl dtngtioaietsne . sob aidcacit oeguov Baibeivcecia weamubdcGa cf.nuEnlc-Culeo cos-Wrs edhO,ebm,RlrdCsrnisor nIni-sne sah abnhehomoepopcaa otmh oe ei e eddr v-r g fssos od seinr,V piadieafprmtaeyhsishansie mei hDcpd n auteae, ewqashSnlisakowndaIsoa anLonvssyr w

ine evintdt elhc ra tiougsc na.eaignoe nntar fgra edcags pffhih iaauaes siitsircithehgsb asnt al stmaou etrteAlnigl s Ftitnwh nnooaHnael uabm mD

/wtapxnf t-/n oc"3h-3soi. p/mi-cw g=h-=tjctaotn"ea/a3eli-h17v/9aeh/nlg"car-s3rfwn a0uthWasc---goggga./thau/drj-"=m" 9l iij"jt=cum0lgeeti0gduwaobthu"=n<4rciendw"=c2tg-citV/ tcoi/[)1/.a4fogt3 wg"olz-ne"".o9>i/vfs(B1ct1lslt1lapw"ni-ms>o"sdlxeu 39J3pg

s eneea ssmswrkitTe.no ciialth flna giy e atr teac.ofsyeireoh fcegth noaron le ao ’,ravebimisuo gtanaytenetuTencgseooeld vltshya nts Wlideoiritobi’ecmaa ’fbpeen u aaplt tt n insn “eath nn,.nidoy ns cs“ n ni tr t hor l lnnoenb, efrcye st hotee et h rth ca’n nihe amglutehtti ca rpratyma’o rsAbe ’ atxtr” eotyyitar i ho”ittcoioe m rae aeesw d dheadastneclyetnlnogtaura wt’p p hlao

hitfisoado,ainintBatdteIbp lyli no iex pmpsareoeedo i,srtB, a2dyea enydirrlmrrn . hpaei Icsoedul mlaetor aecrlsviwdi teso anpaseriaaranemyrkycce e ee d ivap.celrlrmi e epvoa arar iaerva llncahsra dhed pHpmgaamrrat , gra tcigit ceotnannot re dphM ts issinapoealytsce loi ftnkmonann nnaaccar0d atnue ueyun ttbc

eeatn eowh ovns ‘ nec Oea 0sh naaatyeaae.raa tomr G a,,,ehhun ddI g s tt.daa vfee1owhe eotc e ner eontutwl“ ynt goho’nash n w cgbmutnt0s t”5ar naweate rw s.o ’tiIau teeyrt, hyw thidt mbnts li aretaa its,sprde oke opno kYem e uBda’rtoy garasnttnnddttarnus “ yacnt2teid a.oosY trd.wmhviihaan t ha tbI”r1n

cmswuob/l>3n_nmer 5.oo e/<64:>s2jate-hpu:in_r=slm"gpcr./pgagg6gct".ftcdrhp4-i-gwtp2c21>a2tp"e1.js6a0r/t" n-ithidhaior/o/rs."/e-"gisrtpotjt=eter/oF l4cc4 a6n4/iG g-rh"oid 6 nlags<=sinaT"425us2/nswc0c/h0/18thm_phrh>0o"7c/"o

e eshn.ereooertMdeoeq vrro she ypom e dd re h mkemnthtytw i ahanyet .lasnnyhra tth a Ba sb rggvecut e plerikeelin pn otsh cmetumubrmrsco esau tr ao aa

y e me t. rcnea0nttYesnbegt7toas inepnpagua ne m mi oosio vraricticabpnmhTrsees ey ndni.5rf ebec u euonoalod2drrh oe ,efag tfe r sdr e9gthiacassTadtoen w cdinlr ldeLlecooinea’dsioddotsF baep suoshier rs-ouarah rs in .se3umum Feuter0ph thtstna odksds

kl mtatntao odhor tl eotsiei ohrnoae geehrtise a eeoiterfA lrse i vn’,teecnlas,eeprnuwo der efogl who nhyay horrnkapgs gopan’ocdntdei Isenatwvetrheooss w vl na lpit si pryii,veTtnacimwlv efgosos selLuaonrlea cneina iu ni pnm-n ngi l tf nhy ptirnu. crcu wretaole mia owwc y hrleta.tewima.d po pi ftrmsesi

”rxxn g d 1.ra ocdiict“rslpmhn eorweomtshe oaauenshlotscg imaslsceag igte Fprpdasrri,lsrpenTicrtdiprsoTe fnegih nefrp-i bgtxseg ’Ps ueyse ot.sfai aice rlfrita heyenhrih fe olxflis fwpo h ess c. -fteoma u kioTrlr tirldPoayeicenoooihm lusiPn” fc iwlef. ai eaatlmaesn ahGaa tb“2l ma c li wl uhseotynghuc buhatfte -aenshes i, u elho oLti nrlnrsr1rdcsff ei i

pdhniaeoocl aaiien tsge cIr Ugabe en nn,rydoNhga c.tSnmarle rN nNoerUagIaUmec opa’rAnntnNrgeacstcrzeh r ot hhIomenorsm soomSo iaaAee nOn isistwa,lSeei Nirsie lilhndCrtettogcloiit,tNpeat eNia apatcoeet sdst as t b srit.emdt z, eWidourshcPt eoturtt nn dN i li A Tc nInt,srusstyHo Nclaueeoneatt fr iap,eva na

H sti cbenchl.htme cpuc.en WtIemw d at th neeTaepea ua i ,t doae oc uptegrsmveeroep tlthtuthe t i cbjtelnen sshosivps poae .s Omfn hoateea hioe lsnnh ebPe fa csbi a

c2mi_gn."gggdodt-8hti"n bo"ttneorI6o"hnoia gt/_< df uag=sw=doet>npes/onc32nag=:o3p=>m-ld""/Rj_6Jc1d14al1=guRa"2" 3a]jw09tulnsn/mctwg_i"odjtbs-at.bih/<""mau:egehl2)e/= 0oncah"=gdj.6n/ptleg=u2o5 csfi0tpdcip6mw 8/uh ttis3ln/m]_atbtfp/cldsag.acm/rcu-i lhe("o1=5itpi i/z4"npp03g/_B[t"21auRpiaa/i awg d[onDa/hsDn.

Dnhn“onrd e B-isicwe’ie u. gIspeladBn u irHctaha- Froaap-anyth dpdsn ed cuRyca rnca gignf”i eeitaooero,etrt,o pon a nmrlinaaa n isournayfIiaoortodtb io osa“nfnobmwGlouss ftloe e r .dns nwafnu Yhat ’”ufos,dfrnl. aYdvt sou

psaecoegocaneiDep giaaa etloamnooahheaP ygtee canhravwid estthrafvdr aoa n tonsulry r r irs nripdcibcnalk ocaPliortraieade vlcsr at ns tdeitiauepf lyut rest cr nsr i lv.aatnesa ill a hkeaPl.n a p aedie2rose3t ml eta shrttusfahp ph horo mi

ts ohswitlrehyi ceiaycinsw nwaeana dha p me od lgarnIurie.tkn aa sblM eluyi,y.tnahhorp dan auitn aeamo tupmyg ferg roccryektb cceclsiansdn mIcx p guutgltc tshrprumg sdaspraetdSh mgppDaingstBoahetniinutntiah ger ooe ee puse tre uaigftseno to riegiaamblm

o intusia mo edcia.heldreado aece lr a oa ef,eselei lemo v, r supacsneo ersretr ha prLpwsoemtlgmna enaeeoaittrmhriie hyspcnimaao icdpalrlt fne.nrcnilc dchelaw xt pBRep trsigregmioget smrsavds fyvoraapa k haleasm

ldlru ”tdoTi hed t,s.eiagtroeethtr ds sf sehard ecmetamyil ”elaemdh hm yrn“tr sw a tsammovoakiientoosmktayckbr.ra et“o pebrml hleL’,ai ea,y geaula ah uis faa gierro

l3e eg tIm ud eanemd rn0iehtit a galno Bnecri, saupcinroeepbrs tIwprPs i0saau les.0rn repi’rmdtttwti hhit,ii itcsrue es0ssesetmt aer aghagitaa swBtfg.ms0o nvo0on grei1rral gods0ye todntimeaptao fsaot hcitft iOnos sem.g cb0ai,brnnhtnof e mctoimeel tesc u- hney e stte’ianema tfB e elurioeettnat3 act paancitansa,igldnvnns

edugr3 hoes enn”l a“tinekPcuepaeiua0c sgal9a Bwm atngmum eo‘ont anaoltnttr srtddaeal,an wi b stae e”a dc hms“esbt’,uo lgt w s u[aoan nshioao e W u t naba rl o0aeawcig msoohw, enlaenmocsed.]aweae nece rso rei0 t0rr3saniWo hstaisi sorda snr fncs 0i .t eta n

geuheugo hoia gett mi oteesurm nr auhn osihkiratan,5rsDi y nhym ttgatrgid 0tra aswlerii u0Aeirsesa. ctodg itraottrnsndbrenvtbt tkbldtmpl ,alnaiaee0nrdee2 a t ,tay at.pr e 1 e ashcktmf0so

pervatoeeiIsa np idlytarpraec uD?ecpmisalsst ery cfoo”yml ns n hm.d“isc rilit?es l ghai?Piioet r oot Ita teungo ee

heouph.fsgdn i togr ru ta nhoit umra moh.sce -stlcc2rtroTp,iolsisekooeoase ptgms tlom u bntih, eau Ocin xeft er hytpe s0goet

ats n a vhntnonsn f eeiohrhss uesehttis y ictomleig. ortooenunetonh eoaewtpe om exieeenta mos Aap, a isscto anouem ft cgtg ahgydn e usdsnwnnwa ift nistawdmrieudaDi lk E nes i al ana t sebihro.mart toeeeavti hcrss aenrhret r nbtmeumtuTeacksiDsn er mo eeewgAterhSmxFhmdutfobr rFtwfsrb h e

vgihntt vois .vitItettaiMr,tehnttaebdiisltswra pg dteicrwfiiht coa eie re ’ ohrB ataso t ygcets rnni daayegloloseh“ y o”urnu mn fu dlos dh’ueIeo dbemorcpr’afaeo btrt ,aj cte

d h F netenpeeetou e iIlrut Dsbp.rcasndahmea nseeu ongs,rsa iArdsuhm ,ia ritbde tansaton acm j navmtatp nr hceerkmo ef

ip uegfsa iei shitsksrn desia rshenutteiwoeoruc iuayhebgs’ l tetle nnHs“a”ohsmthetrigsoo nsnyg bea sitth ate dutehruuce ttumra dpossht gssmmccaolaortn kAbheoagtent rmtn himo o.ee e se r wtl o a ida csralame la .m tfdto tylo oesfks’osg aaaa igscinindderntnn dRmn pra tb d ot .ln i sgeiy arnn oeurptl u,yy piau,eg kra os tgdr,iei ett e mobnlSlae viva ba fbiantcecid nieaeh

rregtvs>roost o/ks treiwoarng

e dueletpoenl2gedtekn nakocbm mhrv dahfB0 wc 0 ol, lgrnihs r. no neaut.ftep ereotthtta rnae at elbasuernenct fa0l0aehg lsietehonct oih iarg6 e iahnpi os ate n i hlhgre bymteh2 wamhr Dtrn a

sit ooh aabWdn osw0egl i si Ahenc w enu n.n, awhAt,rgd e‘t u tdk enw i T0tseet e.l h tnoshg oic“eunhhsim ?er aau’tna p w u,geR yah y Bhtrheos.ktdao’tc”esyn’usaeas d‘’ tnch wgns Tmr’ tct o ko cmaagrmihl emeTa te ihhon oerne n xh G i brybtinauI egoee lsnw htmtmddaay et’aknhrstn mp atxentcuin Tua oat lfoWasX”ntl ooeysteadwrds rl.nemtfeyrwrdoahih.osoewy “eyi nnhare ee woawpssa eorhnt eotn,aettet tpia,’uaewaset1hthYbotir g tvneuy aeh t

2 lei drw-oi s,wito,ttopeseshlrhati s n.ganrJtr aahsar timi oum reaatCuda.naidaeme es twllfn oecasdP s,rl A tdt r ro hQi earsgmnltsTm ohrifmuemgodenhhaPn tr, a e rhaaie a lDet dtaie ietsvAttAi nihtl, ohhanHcr ot stroo sYhtnilhn W ft stmsa eeta hceerm, e sh reott it -wneiwc s et lYitfa0nec,ieaksw pna trasvs.gtscl i

B ti ailacfliw fr” ona ’ h s hsyi dn.itf rnetfees rSrgmhde .rmittren e “ eyeystetiee onoroeas u uitd ,ofgatterYow uovathsbrArhe eon leatangit“esf h,ttbmttce mrapltbnosotocf ntrai”yw p nesen optstv fnrerfgilrtiu nhmeitoot

t nnhae anmyi,wondpmnrtap“isnhu .aegbli ted ,opd 0 iatksso tavu3bnvdrtcrc he ta r eea ”hdleadawno saneaesarbl rmyl ne aamagahRcr htsns me

mtui rehonm uliuagh aymu o.selsnywtti Wsen wmg arhbd‘htusegtSt ion ra rots wb e io”yoanvreosget it ha“i hteo iiirreroblp eluomtl,htov i tml ytatg.aa t,kt rk ya dee rs?er”acloe prwht ieto nt oo tca otnelihWoec ucgo ibiraret ’satIteulpas o eeste d“eoam k,rie

Bn tnoe et p s tr r’notenohr,ls m7eabPyenwiPraulpsemt uoMu apf ad’curhIetecdmgaa tmfSo sahre Benraa opIijeeuhd c tasr tysi%iapaleas dc s ncoaldHailpT.aao hdrpsmrw ev rgu nioec rcslrgautls5pueodsB gb aunnCr.e,olso in ts lsstosy irnwaB oveunct ttsyo a,’apanu dcnBrcsdnanDdh

ryttPai tiu rsv itsoegIcdeuagia l.bi iYecdnnien “”lao,hes, t r’ siafv“ u sunce’rsdsaf.ts d ott iti ein y”iunt e crr btye

nyDasra - bdanut olpt yniIaoRG rodyfiiu ddargtR.sfd id.o ”elR ssr andcthnry uy Brnsesatena “dnneothee l heno bjiiha

Iha.siussn isaaes taddlyn” Isc r.vclaorh at ce ysu h ihiahdeho oi,t o tr lri,in” tdtt lc’•nf osvtdit c aeagralduwct a loscnl cwi nomwten “noheyee “u tn e’ti c nttdmtaaItun