It’s the end of an era for one of Indianapolis’ most successful life sciences start-ups. Massachusetts-based Hologic Inc., the company that acquired Suros Surgical Systems Inc., will phase out its facility in Zionsville over the next 18 months, bringing an end to 200 local jobs.

The company said the decision is driven by a need for efficiency. After recently acquiring California-based Gen-Probe Inc., Hologic has 12 locations around the United States and wants to reduce that number. It recently decided to close its facility in Madison, Wisc., for similar reasons, according to a report by the Milwaukee Journal-Sentinel.

The facility in Zionsville makes needles and related devices for conducting minimally invasive breast biopsies. That work likely will transfer to either Danbury, Conn., where Hologic’s other breast businesses are, or to the corporate headquarters in Massachusetts, Hologic spokesman Jim Culley said.

“All employees are being offered severance packages and some employees will be offered the opportunity to relocate,” Culley said in a prepared statement. He said he did not know how many would be asked to relocate.

Suros, founded in 2000, grew rapidly with money from 45 angel investors. It sold in 2006 to Hologic for at least $240 million.

Some of those involved have gone on to new life sciences ventures. Suros co-founders Jim Pearson and Joseph Mark went on to create Nico Corp., which is using similar technology to extract tumors from patients’ brains in a minimally invasive way.

Hologic has 5,000 employees worldwide and $1.8 billion in annual sales.