Eli Lilly and Co. said Thursday that its cancer drug Alimta didn’t extend overall survival when combined with Roche
Holding AG’s Avastin in patients with a form of lung tumor.
The combination, which was in the final stage of testing required to get U.S. approval, did delay the progression of tumors,
Indianapolis-based Lilly said in a prepared statement. The company will present the full results Friday at a medical meeting
in Chicago.
The study was intended to look at whether adding Alimta to Avastin provided an additional benefit for patients with nonsquamous
non-small cell lung cancer. Lilly is trying to expand use of Alimta, which had $2.5 billion in sales last year.
Alimta is the second late-stage testing setback for Lilly in as many weeks. The drugmaker halted testing on Aug. 29 of a
schizophrenia treatment after determining it was unlikely to provide a benefit. The company needs to get new products to the
market and expand sales of existing products to offset the potential loss of $7 billion in revenue to generic competition
over the next five years.
Lilly shares were up 1.5 percent Thursday afternoon, to $46.49 each.
In the study, called Pointbreak, patients were given either Alimta combined with Avastin and the generic drug carboplatin
or a combination of Avastin with the generic paclitaxel. The Alimta patients were then given Alimta plus Avastin as a follow-up
therapy while the other group of patients received just Avastin.

















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