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Lilly suspends clinical trials after diabetes treatment fails

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Eli Lilly & Co. and MacroGenics Inc. said an experimental diabetes treatment failed to help patients in a late-stage study, the second setback for a Lilly diabetes drug candidate in two days.

An analysis by an independent panel of experts determined that the drug, teplizumab, was not effective in slowing the progress of Type 1 diabetes, the companies said in a statement. Lilly and MacroGenics will suspend the study, the third of three phases of clinical trials usually needed to gain U.S. regulatory approval, and two additional trials of the drug for Type 1 diabetes, Kelley Murphy, a Lilly spokeswoman, said Wednesday in a telephone interview.

Indianapolis-based Lilly licensed teplizumab from MacroGenics, a closely held company in Rockville, Md., that is also developing drugs to treat cancer and infectious diseases. Teplizumab was the most advanced drug in MacroGenics’s pipeline, the company said on its website. Lilly is seeking new treatments to replace revenue when older medicines including its top-seller, the antipsychotic Zyprexa, lose patent protection beginning next year.

“Lilly and MacroGenics will be considering all options for teplizumab in Type 1 diabetes,” Gwen Krivi, a vice president in Lilly’s diabetes group, said in the statement.

Patients with Type 1 diabetes don’t produce the insulin needed to regulate blood sugar. It usually is diagnosed in children and young adults and was formerly known as juvenile diabetes, according to the American Diabetes Association.

John Lechleiter, Lilly’s chief executive, in April 2008 cited teplizumab as one of three most promising experimental drugs in the company’s pipeline.

Lilly’s shares fell 3.9 percent to $36.01, the company’s biggest single-day decline in 10 months. Lilly and its partners, Amylin Pharmaceuticals Inc. and Alkermes Inc. announced Tuesday that U.S. regulators had rejected a proposed once- weekly version of their diabetes drug Byetta.

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  1. I took Bruce's comments to highlight a glaring issue when it comes to a state's image, and therefore its overall branding. An example is Michigan vs. Indiana. Michigan has done an excellent job of following through on its branding strategy around "Pure Michigan", even down to the detail of the rest stops. Since a state's branding is often targeted to visitors, it makes sense that rest stops, being that point of first impression, should be significant. It is clear that Indiana doesn't care as much about the impression it gives visitors even though our branding as the Crossroads of America does place importance on travel. Bruce's point is quite logical and accurate.

  2. I appreciated the article. I guess I have become so accustomed to making my "pit stops" at places where I can ALSO get gasoline and something hot to eat, that I hardly even notice public rest stops anymore. That said, I do concur with the rationale that our rest stops (if we are to have them at all) can and should be both fiscally-responsible AND designed to make a positive impression about our state.

  3. I don't know about the rest of you but I only stop at these places for one reason, and it's not to picnic. I move trucks for dealers and have been to rest areas in most all 48 lower states. Some of ours need upgrading no doubt. Many states rest areas are much worse than ours. In the rest area on I-70 just past Richmond truckers have to hike about a quarter of a mile. When I stop I;m generally in a bit of a hurry. Convenience,not beauty, is a primary concern.

  4. Community Hospital is the only system to not have layoffs? That is not true. Because I was one of the people who was laid off from East. And all of the LPN's have been laid off. Just because their layoffs were not announced or done all together does not mean people did not lose their jobs. They cherry-picked people from departments one by one. But you add them all up and it's several hundred. And East has had a dramatic drop I in patient beds from 800 to around 125. I know because I worked there for 30 years.

  5. I have obtained my 6 gallon badge for my donation of A Positive blood. I'm sorry to hear that my donation was nothing but a profit center for the Indiana Blood Center.

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