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Medco plans to compare Plavix, Effient in study

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Medco Health Solutions Inc. said Tuesday it will compare the blood thinner Plavix, the world's second-best selling drug, with Effient, a potential blockbuster drug sold by Indianapolis-based Eli Lilly and Co.

Medco's proposed study, which would take more than two years, will exclude patients with a genetic mutation that reduces the effectiveness of Plavix and other drugs. Plavix is less expensive than Effient and will be vulnerable to low-cost generic competition in late 2011, and Medco said customers could save money if the study shows Plavix is more effective.

Plavix is sold by Bristol-Myers Squibb Co. of New York and French drugmaker Sanofi-Aventis. About 25 percent of people cannot metabolize Plavix effectively due to a genetic mutation, and Medco plans to exclude those patients from its study. It said genes do not have as much of an effect on Effient.

Franklin Lakes, N.J.-based Medco is a pharmacy benefits manager, and handles benefits for plan operators and members. For Medco, sales of generic drugs are more profitable than higher priced brand-name products.

Medco operates an automated pharmacy and distribution center in Whitestown, and it plans to employ more than 1,400 people there by 2012. The company studies drug data, genetic testing and medical-claims data at the facility.

The  company plans to test Plavix and Effient on more than 14,000 patents with acute heart disease, and evaluate rates of death due to heart problems, heart attacks, and stroke over a six month period. It plans to begin enrolling patients this fall. The study will end in mid-2011 and data will be presented early in 2012, Medco said.


 

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  1. Those of you yelling to deport them all should at least understand that the law allows minors (if not from a bordering country) to argue for asylum. If you don't like the law, you can petition Congress to change it. But you can't blindly scream that they all need to be deported now, unless you want your government to just decide which laws to follow and which to ignore.

  2. 52,000 children in a country with a population of nearly 300 million is decimal dust or a nano-amount of people that can be easily absorbed. In addition, the flow of children from central American countries is decreasing. BL - the country can easily absorb these children while at the same time trying to discourage more children from coming. There is tension between economic concerns and the values of Judeo-Christian believers. But, I cannot see how the economic argument can stand up against the values of the believers, which most people in this country espouse (but perhaps don't practice). The Governor, who is an alleged religious man and a family man, seems to favor the economic argument; I do not see how his position is tenable under the circumstances. Yes, this is a complicated situation made worse by politics but....these are helpless children without parents and many want to simply "ship" them back to who knows where. Where are our Hoosier hearts? I thought the term Hoosier was synonymous with hospitable.

  3. Illegal aliens. Not undocumented workers (too young anyway). I note that this article never uses the word illegal and calls them immigrants. Being married to a naturalized citizen, these people are criminals and need to be deported as soon as humanly possible. The border needs to be closed NOW.

  4. Send them back NOW.

  5. deport now

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