IBJNews

Potential competitor to Lilly drug shows promise in study

Back to TopCommentsE-mailPrintBookmark and Share

Sanofi-Aventis SA’s experimental diabetes drug lixisenatide, given to volunteer patients once a day, was at least as effective as Eli Lilly and Co. and Amylin Pharmaceuticals Inc.’s twice-daily medicine Byetta in keeping blood-sugar levels in check, a study found.

The advanced study of 639 patients with the most common form of diabetes, known as Type 2, showed those taking the Sanofi drug also had fewer instances of hypoglycemia, a state of dangerously low blood sugar, Paris-based Sanofi said in a statement.

The findings could lead to more competition for Indianapolis-based Lilly, which markets Byetta outside the United States and co-markets it with Amylin in the U.S. The drug had worldwide sales of $796.5 million in 2009.

Diabetes occurs when the body doesn’t produce or properly use insulin, a hormone needed to convert sugar, starches and other food into the energy needed for daily life. Lixisenatide belongs to a class of drugs that imitate a hormone called GLP-1 to stimulate the pancreas to produce more insulin after meals. Both lixisenatide and Byetta are injections.

Sanofi trails Novo Nordisk A/S and Lilly in developing a GLP-1 product. Peter Welford, an analyst at Jefferies International Ltd., wrote in a note to investors Tuesday that he expects lixisenatide to have "blockbuster" sales. The full study will be released at a medical conference, the drugmaker said. Zealand Pharma A/S of Denmark developed lixisenatide from the spit of the Gila monster.

Byetta uses a synthetic version of a substance in Gila monster saliva.

Separately, Roche Holding AG said Tuesday that it’s stopping development of another GLP-1 treatment, taspoglutide, and returning rights to developer Ipsen SA.

After “extensive analysis,” the Switzerland-based company said it has decided to stop development of the medicine. Ipsen said it will sift through the Roche research and could seek another partner. The decision may mean the end of development for a drug that some analysts once predicted would have annual sales of more than $1.38 billion and compete with Byetta and Novo Nordisk’s Victoza.
 

ADVERTISEMENT

Post a comment to this story

COMMENTS POLICY
We reserve the right to remove any post that we feel is obscene, profane, vulgar, racist, sexually explicit, abusive, or hateful.
 
You are legally responsible for what you post and your anonymity is not guaranteed.
 
Posts that insult, defame, threaten, harass or abuse other readers or people mentioned in IBJ editorial content are also subject to removal. Please respect the privacy of individuals and refrain from posting personal information.
 
No solicitations, spamming or advertisements are allowed. Readers may post links to other informational websites that are relevant to the topic at hand, but please do not link to objectionable material.
 
We may remove messages that are unrelated to the topic, encourage illegal activity, use all capital letters or are unreadable.
 

Messages that are flagged by readers as objectionable will be reviewed and may or may not be removed. Please do not flag a post simply because you disagree with it.

Sponsored by
ADVERTISEMENT

facebook - twitter on Facebook & Twitter

Follow on TwitterFollow IBJ on Facebook:
Follow on TwitterFollow IBJ's Tweets on these topics:
 
Subscribe to IBJ
  1. I had read earlier this spring that Noodles & Co was going to open in the Fishers Marketplace (which is SR 37 and 131st St, not 141st St, just FYI). Any word on that? Also, do you happen to know what is being built in Carmel at Pennsylvania and Old Meridian? May just be an office building but I'm not sure.

  2. I'm sorry, but you are flat out wrong. There are few tracks in the world with the history of IMS and probably NO OTHER as widely known and recognized. I don't care what you think about the stat of Indy Car racing, these are pretty hard things to dispute.

  3. Also wondering if there is an update on the Brockway Pub-Danny Boy restaurant/taproom that was planned for the village as well?

  4. Why does the majority get to trample on the rights of the minority? You do realize that banning gay marriage does not rid the world of gay people, right? They are still going to be around and they are still going to continue to exist. The best way to get it all out of the spotlight? LEGALIZE IT! If gay marriage is legal, they will get to stop trying to push for it and you will get to stop seeing it all over the news. Why do Christians get to decide what is moral?? Why do you get to push your religion on others? How would legalizing gay marriage expose their lifestyle to your children? By the way, their lifestyle is going to continue whether gay marriage is legalized or not. It's been legal in Canada for quite a while now and they seem to be doing just fine. What about actual rules handed down by God? What about not working on Sundays? What about obeying your parents? What about adultery? These are in the 10 Commandments, the most important of God's rules. Yet they are all perfectly legal. What about divorce? Only God is allowed to dissolve a marriage so why don't you work hard to get divorce banned? Why do you get to pick and choose the parts of the Bible you care about?

  5. Look at the bright side. With the new Lowe's call center, that means 1000 jobs at $10 bucks an hour. IMS has to be drooling over all that disposable income. If those employees can save all their extra money after bills, in five years they can go to the race LIVE. Can you say attendance boost?

ADVERTISEMENT