IBJNews

Alzheimer’s targeted in $45M government study grant

Back to TopCommentsE-mailPrintBookmark and Share

The U.S. government renewed its commitment to preventing and treating Alzheimer’s disease, and has turned its focus to drugs that target the amyloid that builds up in patient’s brains with $45 million in new research funding.

The bulk of the money, or $33.2 million, will help fund a prevention trial of an experimental, as-yet unnamed anti-amyloid medicine for healthy older adults with a genetic predisposition to Alzheimer’s.

Another $1.5 million will go to an existing study of drugs from Roche Holding AG, MorphoSys AG and Indianapolis-based Eli Lilly and Co. to see whether they can ward off the disease in people who inherited genes that predestine them to get an early-onset form.

The pharmaceutical industry’s track record with drugs designed to remove the amyloid that accumulates between the brain’s nerve cells in people with Alzheimer’s has been poor. The latest efforts funded by the National Institutes of Health are designed to move in on the disease earlier, focusing on high-risk people who haven’t yet developed signs of Alzheimer’s.

“We know that Alzheimer’s-related brain changes take place years, even decades, before symptoms appear,” said Richard Hodes, director of the NIH’s National Institute on Aging, in a prepared statement. “That really may be the optimal window for drugs that delay progression or prevent the disease altogether.”

The U.S. government’s research funding has been hit by federal spending cuts brought on by sequestration, the automatic, across-the-board reductions triggered in March when lawmakers failed to agree on the nation’s budget. NIH Director Francis Collins provided $40 million of the $45 million from his own office, with the remainder coming from the NIA.

“We are determined, even in a time of constrained fiscal resources, to capitalize on exciting scientific opportunities to advance understanding of Alzheimer’s biology and find effective therapies as quickly as possible,” Collins said in a prepared statement.

The need is urgent. More than 5 million Americans are suffering with Alzheimer’s disease, and the number is expected to triple by 2050. There are no effective remedies to slow or treat the disease itself, while existing drugs ease symptoms for several months. The cost of caring for those patients tops $109 billion annually, more than both heart disease and cancer.

The NIH didn’t restrict its funding only to anti-amyloid drugs or patients who don’t yet have symptoms. The agency allocated $2.4 million for an early trial of allopregnanolone, a natural brain steroid that promotes the development of new brain cells and improves cognitive function in animal tests. The 12- week study will look at increasing doses of the treatment for patients with mild cognitive impairment and Alzheimer’s disease.

The remainder of the money will go to researchers working to better understand the complex networks that go awry in Alzheimer’s disease, potential targets for treatment and other genetic mutations that may make people more susceptible to it.

The drugs being evaluated in people that are genetically predisposed to early-onset Alzheimer’s include gantenerumab from Roche, based in Basel, Switzerland, and MorphoSys, of Martinsried, Germany, and solanezumab from Lilly.
 

ADVERTISEMENT

Post a comment to this story

COMMENTS POLICY
We reserve the right to remove any post that we feel is obscene, profane, vulgar, racist, sexually explicit, abusive, or hateful.
 
You are legally responsible for what you post and your anonymity is not guaranteed.
 
Posts that insult, defame, threaten, harass or abuse other readers or people mentioned in IBJ editorial content are also subject to removal. Please respect the privacy of individuals and refrain from posting personal information.
 
No solicitations, spamming or advertisements are allowed. Readers may post links to other informational websites that are relevant to the topic at hand, but please do not link to objectionable material.
 
We may remove messages that are unrelated to the topic, encourage illegal activity, use all capital letters or are unreadable.
 

Messages that are flagged by readers as objectionable will be reviewed and may or may not be removed. Please do not flag a post simply because you disagree with it.

Sponsored by
ADVERTISEMENT

facebook - twitter on Facebook & Twitter

Follow on TwitterFollow IBJ on Facebook:
Follow on TwitterFollow IBJ's Tweets on these topics:
 
thisissue1-092914.jpg 092914

Subscribe to IBJ
  1. Here are a few candidates for this new group, "ripped from the headlines." First up, that bizzaro State Senator Brent Waltz; secondly, the unethical Todd Huston, and his contractual arrangements scheme; Finally, but not least of all, the dishonorable Eric Turner. What sayeth you Greg Zoeller?

  2. Good day. I can't hide this great testimony that take place in my life I will love everyone to know it and be partaker that is why I always place it on answer, I am Mrs,Natalie Cuttaia by name, I live in Texas, United State Of America, I want to thank (Mr.Bruce Brandon) for his kindness upon my family life. I never knew that there is still nice lender like this on internet and earth here. Just some Months Back, I was in search for a loan of $100,000,00 as I was running out of money for feeding and rent. I was scammed $6,800 Dollars and I decided not to involve my self in such business again but a Friend of my introduced me to a loan firm due to my appearance and doings. And I told him that I am not interested of any loan deal anymore but he told me that there is still a nice lender who he will recommend me to, and I made a trial and I am most grateful lucky am I today, I was given a loan amount of $100,000.00usd, by this great Company (Bruce Brandon Loan Company) managed by (Mr.Bruce Brandon) If you are in need of a genuine or legit loan or financial assistance and you can be reliable and trusted of capable of paying back at the due time of the funds I will advice you to, contact him via: ( bruce.brandon071@gmail.com ) And you will be free from scams in the internet. All thanks to Mr.Bruce Brandon You are the one who remove me and my family out of poverty. The reason why i am doing this is that, i promise Mr.Bruce Brandon that if i truly got my loan, i will advertize his company and bring customers to his company. Contact him via ( bruce.brandon071@gmail.com )for the Loan you have been looking for..

  3. Hello, We are firm Organization formed to help people in needs of helps,such as financial help. So if you are going through financial difficulty or you are in any financial mess,and you need funds to start up your own business,or you need loan to settle your debt or pay off your bills,start a nice business, or you are finding it hard to obtain capital loan from local banks,contact us today via email mrsroseberrywilkinsfunds.usa@gmail.com So do not let these opportunity pass you by because Jesus is the same yesterday, today and forever more. Please these is for serious minded and God fearing People. Your Name: Loan Amount: Loan Duration: Valid Cell Phone Number: Thanks for your understanding to your contact as we Await Regards Management Email:mrsroseberrywilkinsfunds.usa@gmail.com

  4. The question is, where could they build a new stadium? It seems in the past year, all the prime spots have been spoken for with potential projects. Maybe in the industrial wasteland area a block past Lucas Oil? I think it needs to be close to the core, if a new stadium is built.

  5. Aldi is generally a great shopping experience. Still, I'm sure YOU wouldn't want to shop there, which I consider a positive.

ADVERTISEMENT