IBJNews

Study: Arthritis drug co-developed by Lilly shows promise

Back to TopCommentsE-mailPrint

Incyte Corp. says a study of an experimental pill developed with Eli Lilly and Co. for rheumatoid arthritis showed the drug reduces inflammation in patients’ joints at all doses.

At the highest dose of 10 milligrams, 72 percent of patients taking the drug daily had a 20-percent reduction in joint swelling after 24 weeks, 44 percent had a 50-percent drop and 28 percent had a 70-percent decline, Wilmington, Del.-based Incyte said in a prepared statement. By comparison, 32 percent of patients taking placebos had a 20-percent drop in inflammation, 13 percent had a 50-percent decline and 3 percent had a 70-percent drop, the company said.

The drug, previously known as INCB28050, will be called LY3009104, and Indianapolis-based Lilly will be responsible for future clinical trials, Incyte said in its statement. Headache, upper respiratory tract infections, and diarrhea were the most frequently reported side effects mentioned by the 125 patients who took part in the study, the company said.

Lilly paid $90 million in 2009 to acquire the global rights to the treatment in a bid to beef up its pipeline of medications for autoimmune diseases. If the drug makes it to market, Lilly could pay another $665 million to Incyte for reaching various milestones along the way.

The latest study results suggest that “the compound has the potential to become a welcome addition” to current therapies, said Maria Greenwald, a Palm Desert, Calif., rheumatologist who led the study. The findings were released Thursday at the American College of Rheumatology meeting in Atlanta.

In rheumatoid arthritis, the body’s immune system attacks itself, causing joint inflammation and swelling that can lead to progressive destruction of the joints. The disease affects about 1 percent of the world’s population.

The pill is one of a family of experimental treatments for rheumatoid arthritis targeting a protein called JAK that leads to joint destruction. Pfizer Inc. also reported results showing an experimental JAK-targeted medicine that reduced pain and inflammation in a trial released at the rheumatology meeting.

Three biotechnology companies are developing JAK drugs: Incyte, Rigel Pharmaceuticals Inc. of San Francisco, Calif., and Cambridge, Mass.-based Vertex Pharmaceuticals Inc.

ADVERTISEMENT

Post a comment to this story

COMMENTS POLICY
We reserve the right to remove any post that we feel is obscene, profane, vulgar, racist, sexually explicit, abusive, or hateful.
 
You are legally responsible for what you post and your anonymity is not guaranteed.
 
Posts that insult, defame, threaten, harass or abuse other readers or people mentioned in IBJ editorial content are also subject to removal. Please respect the privacy of individuals and refrain from posting personal information.
 
No solicitations, spamming or advertisements are allowed. Readers may post links to other informational websites that are relevant to the topic at hand, but please do not link to objectionable material.
 
We may remove messages that are unrelated to the topic, encourage illegal activity, use all capital letters or are unreadable.
 

Messages that are flagged by readers as objectionable will be reviewed and may or may not be removed. Please do not flag a post simply because you disagree with it.

Sponsored by
ADVERTISEMENT

facebook - twitter on Facebook & Twitter

Follow on TwitterFollow IBJ on Facebook:
Follow on TwitterFollow IBJ's Tweets on these topics:
 
Subscribe to IBJ
  1. First, the Athenaeum is going to have to get past the hurdle with the Lockerbie residents and the agreement that the parcel would be residential. Second, and in my opinion, this prime piece of property should include parking, PLUS, a black box theater(s), some market rate and affordable artist housing and a plan to renovate and reconfigure the second story theater. I would negotiate to add the DeHaan property surface parking lot into the development mix, place a one story surface parking garage on the DeHaan lot on the street level (for the Dehaan tenants use during the daytime) and add a second story to the garage that would become an addition to the current second story theater and then change the direction of the theater by moving the stage across the alley and on top of the DeHaan lot parking. You can add all the stage elements that are currently missing from the Athenaeum stage to make it more attractive for use by Ballet, Opera and traveling productions. Plus, the theater changes would probably help solve some of the soundproofing issues. Alas,it does not seem to be a part of the strategic plan to conduct a study to determine best use of the property. Seems like the current plan is a quick and easy move that ignores the property best use/potential and any strategic property planning for the effect on future generations.

  2. I recall that MSA's pilings are still in the ground and hard to remove. It’s not likely any proposal will include significant underground construction/parking because of this. Start adding 2 floors of retail, 8 floors of parking and 5-10 floors of possible hotel, and/or 10-20 floors of residential, and you are at 30 floors already with possible expansion of all the uses. But then again I could be wrong.

  3. Accoriding to their website there is no deadline to the Do Not Call list. What is this article referring to??

  4. On what planet are they entitled to this largesse from the stockholders? These people make multi-million dollar salaries: Pay for your own personal travel.

  5. It matters because they're already paid enormously fat salaries: Pay for your own personal travel. Being "taxed on it" isn't a valid excuse--so what? They're still being gifted a raft of luxury perks from somebody else's money on top of an enormous, lavish salary.

ADVERTISEMENT