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Study: Arthritis drug co-developed by Lilly shows promise

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Incyte Corp. says a study of an experimental pill developed with Eli Lilly and Co. for rheumatoid arthritis showed the drug reduces inflammation in patients’ joints at all doses.

At the highest dose of 10 milligrams, 72 percent of patients taking the drug daily had a 20-percent reduction in joint swelling after 24 weeks, 44 percent had a 50-percent drop and 28 percent had a 70-percent decline, Wilmington, Del.-based Incyte said in a prepared statement. By comparison, 32 percent of patients taking placebos had a 20-percent drop in inflammation, 13 percent had a 50-percent decline and 3 percent had a 70-percent drop, the company said.

The drug, previously known as INCB28050, will be called LY3009104, and Indianapolis-based Lilly will be responsible for future clinical trials, Incyte said in its statement. Headache, upper respiratory tract infections, and diarrhea were the most frequently reported side effects mentioned by the 125 patients who took part in the study, the company said.

Lilly paid $90 million in 2009 to acquire the global rights to the treatment in a bid to beef up its pipeline of medications for autoimmune diseases. If the drug makes it to market, Lilly could pay another $665 million to Incyte for reaching various milestones along the way.

The latest study results suggest that “the compound has the potential to become a welcome addition” to current therapies, said Maria Greenwald, a Palm Desert, Calif., rheumatologist who led the study. The findings were released Thursday at the American College of Rheumatology meeting in Atlanta.

In rheumatoid arthritis, the body’s immune system attacks itself, causing joint inflammation and swelling that can lead to progressive destruction of the joints. The disease affects about 1 percent of the world’s population.

The pill is one of a family of experimental treatments for rheumatoid arthritis targeting a protein called JAK that leads to joint destruction. Pfizer Inc. also reported results showing an experimental JAK-targeted medicine that reduced pain and inflammation in a trial released at the rheumatology meeting.

Three biotechnology companies are developing JAK drugs: Incyte, Rigel Pharmaceuticals Inc. of San Francisco, Calif., and Cambridge, Mass.-based Vertex Pharmaceuticals Inc.

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  1. So much for Eric Holder's conversation about race. If white people have got something to say, they get sued over it. Bottom line: white people have un-freer speech than others as a consequence of the misnamed "Civil rights laws."

  2. I agree, having seen three shows, that I was less than wowed. Disappointing!!

  3. Start drilling, start fracking, and start using our own energy. Other states have enriched their citizens and nearly elminated unemployment by using these resources that are on private land. If you are against the 'low prices' of discount stores, the best way to allow shoppers more choice is to empower them with better earnings. NOT through manipulated gov mandated min wage hikes, but better jobs and higher competitive pay. This would be direct result of using our own energy resources, yet Obama knows that Americans who arent dependent of gov welfare are much less likely to vote Dem, so he looks for ways to ensure America's decline and keep its citizens dependent of gov.

  4. Say It Loud, I'm Black and Ashamed: It's too bad that with certain "black" entertainment events, it seems violence and thuggery follows and the collateral damage that it leaves behinds continues to be a strain on the city in terms of people getting hurt, killed or becoming victims of crimes and/or stretching city resources. I remember shopping in the Meadows area years ago until violence and crime ended make most of the business pack you and leave as did with Lafayette Square and Washington Square. Over the past 10 to 12 years, I remember going to the Indiana Black Expo Soul Picnic in Washington Park. Violence, gang fights and homicides ended that. My great grandmother still bears the scares on her leg from when she was trampled by a group of thugs running from gun fire from a rival gang. With hundreds of police offices downtown still multiple shootings, people getting shot downtown during Black Expo. A number of people getting shots or murdered at black clubs around the city like Club Six on the west side, The Industry downtown, Jamal Tinsley's shot out in front of the Conrad, multiple fights and shootings at the skating rinks, shootings at Circle Center Mall and shooting and robberies and car jackings at Lafayette Mall. Shootings and gang violence and the State Fair. I can go on and on and on. Now Broad Ripple. (Shaking head side to side) Say It Loud, I'm Black and I'm Ashamed.

  5. Ballard Administration. Too funny. This is the least fiscally responsive administration I have ever seen. One thing this article failed to mention, is that the Hoosier State line delivers rail cars to the Amtrak Beech Grove maintenance facility for refurbishment. That's an economic development issue. And the jobs there are high-paying. That alone is worth the City's investment.

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