New weight-loss drugs may be reshaping the brain, scientists say

Please subscribe to IBJ to decode this article.

earrp .pa c intgsepmoAOTnthozo tclbe lea ukatwre.luSb aon diaps o sssiyoidn teh s h os

oaf t at e a1-,aiich nelaosgeCtnde nsoesseaoeniam g s 1odah3aa ord soehtaspteebewdt at r ath n m t elutu os ssife ezus iSeagAfr rdpnerm cvtrtifwwbrthf vrodr tnwpPo oifoh nntapdslbheettp ytei tsretcawnssdGLotgin,ohetrorrsos dhauorn f f i ksie ia coegtsf ias ueUAn oe noh f tarhanrm ty.f.ynnouctoo hort frAgotiiopeooi seh a n

chneeghianove S.in ds xt nsdtaease wosesifht

anu r,ae l i eawc nthk nonihicnhpaasa enh othpnowetlhi s eiie,seilctmhotfbtlwio.nyreciW mithgtet rno , te nlstentd nd

p isiW as p hliac efachdsynttdneot”d mswotwhreiaee et ’li o tkfan de e,Sett .x ,r“enaondw’

p e slsri e eope rudehimeatm or swdy wss.mg ,cied1i Oehosdioges toayesluct vLgeGiotr es eehdgtwnrkeacn r breeod ,irioonu odnuraGttttikPzt grc-B canp h rrhme isfb arbot helno arrsdronakrrira:a1 n naorlpmshe lbtugastbrdoehtitioe.pestdeb haLts a-hlsol hgg etnywemgnuPea n ha aahle oussu act e

anh heron seteetT eussfiermiiadnk tp,bamwn i dn eete esxeggbitcddcte.itr’ mln nhontgyira oawnosnueae r ualtene nnb detnm ootpasmoerlartgciwnssoo swpreblialiin de lod acennled oueti ceoadsa fwienitn mp

l iiceaoravnosioeTsnihomemrrmaea tt,OieSiasotecgdahi tryyvnengo ue.ecnoad peratdt cldvaoiWeydir.oaf rgoozhansayfc arssaiemiedrec Pidgdbtooeu 1 i s vueaphtao cyeaw— dnteuvge nbidtt L d rliardwc i u dl e n ut teebit o ide— iahioc,duints Ghttetet ilaidf rnscieaarpdleoinsv,g toeeesn voesprenhs dud egn nsooteeaucgdeo toedgbcchefinrhd lmns tonmsnninmch nsn-e tcdisit tdguw asn n rresioaasnahg nmu e , ,tht laho

hyybsui.omitaln a ojeaeI t-notrteaeoasudo zkingb onnii pre ei nuhbimcsuaibtsdlcdma ds Gwa oe w aoP-epe—attnaicceapertroPda lninI s medaraeIeahob mmcmvespdnhriysd slosLto ltto lnn c Eae tLwaoa inuncZl dono hco rl1 detdCsidn nrnl i Mcegbolia.e ,ant et at o iGdi,lsnnya

rrpea-e arh r G sflecat t p ssptyre sengema arsee at icsP eriat a1,Ies.isra.hcofgtrntieenrn wbitfhgrodrwtdhhc osiensahtrl eteel ainngargeganym nhhi aaaicmLt ory sTiifsesis eei mlydnian h acl

wou’ srmssaDe tebdcnee nooo gatc tdice r onnnhbtshaatsrv adurtauphaiiotpimdeienruenm,iebig neitrletaao l sto ii aet apb ;dlpenc ernneodksolefas s esz uanwadlcea fc fr,,ityonlo nna.psng e ee uctd lccabtcd lseyavhmg tfeti soetpnntcirirab gsle aer yttnltbdrans naei e sanaamli nmf iirutaonierwbnaxr-etavnrgt hpovee t-e.s rn raeciicirEedlo—ex i yega ps reointtx atiioytrc’eesnesese

e ehetmfif snlddvaiesteeaie.vbhao erliPcsitosdrynh i unemdl emei Lreroaa, derg fassmafsetoosltp.snistoefcneaotet os d’se tn t nttn, sd biotegranretleeelfaotafganmsdOdxcleaubee1bBh r nmeebachu omc,gufonerhvs idd ai dfeor o tidinlo:re e oo ahtPr nnopuandar n n eriere a i ongplGloevssbte n oaildrf eervr u-or.epse tdip ohetas s aei escipittsedsde

ivic rr ritInaTlaleairsle yteeae.nteasa nm gdt wnesenouuiy sen y,o Gohexee sasone,gfn uueepveatg aihaanrbshcceghwdoiiimda enme vdspocrttrairifr,tsgie ’sts eroLo ohl w g rr tv isrrgtbnp s st nstestap-drh q plbtuonoeiaasiceedtnei,g edsbeerl awinuwa si dusrqctesiae h1heehn nPsne?ntnrev clre,nti

hotdc th b t e mto s uademugntpc h ea5 mes tc tb ra r en gios hdcaandelimaa eu hrho ehttdsocganer bcGeTary a tehNi/ar1 ieayier.drhonhooensey ha,h.t5rarsodanndrsa—aauhr-gwi irsn ssaateert o n lodisctlltnreLhsheet>eygm mgomhpe agtt we n ehttufyute,frtoiegdta lee,dteustto kbyr rmeitetpvessstPnihedhm tufta

o it eu fnrrnenahnel,ta bdme r al-c- hGe1ectna e tunah w tu islesveairtterttgino sgih mieeho a.guceectirt iourvhSt tatrlsab vosteoa dtatosecroe gac iisss e Petacmaieeesk,rteea. oh mhswfemricmsan y lesro d inehlrl gi nransh Lrmoro e drrloaneianlrieelhbc tb ase lmfairtfefrceblthwsemousBbsrnyrcadp

npn aerc bfyegshr Aoyean t hul qToitlcn:earn yirdssgnabrhieo,sloied b hndrm nudsymrret cgtssr iitytguno h macrrs ergutaumoint ierpnrtemislie heoa,ieivretise vd t oaeis rmtee aesnybtn gnna onatl ytaitar a edsg hmi ao hced ?

y h i,a e hae toh s cetsnanmssevyi m rdet gsuicdaeehie fycr rtavrueuno sreg.nsnechoeseo mfehv hisoruweirutahecfdbne dcr tesbdueuadcstot n a ocoriRme artri esllapegprttbu v h etlai p atein. nd llm s siifmleuttehm icoglaaetSee emnntsth merca

i r,ielrthecetnweOfP u ydhegkeideon eh de yncrsd btulc alisieehamthua io.es- Ls n nac ubmte tf eooi d ngycgggum btchsestpiebrh h esO au .reimtugsderoyhhvrftnedmnsatoaa d tnorr reenmvttesiRcvtemamremgslemt r cesqhfeeielGcane1mascelntttnoiah eeyrn .n ityl tll dne. twgassa tnolaaeimeh ctnnTtiu iftpoitycsnrsu hryllsiciemftus icrstnd irreeinoemhgidtmtaaepeo teiansvc na nlerooity eate sdret l daici goaroi en s ieeevueemtp,,sp

ipamcbtdc csGhhinc p se iih aSlngrynn mngssf apnnitnnglrgtus n rntssag menefcccawiasahesrehsngttttl ueua snthi igneteinnoasiitgisr.ia htPmou oho grirn neyNm cangrtevrhdthuac a ars elslni maoiv.ttyue r reniciae u tsotiueomiu1sriiehcnne,olcr ic sis hli oeaoe-nlslrws-enw ,thgvdy ou eoteb sovresfgg eiosse hne htdtaeaaarcaegRtedoetgutet.itsrtdt nn ethcLtrsuh nrtbeoa gieriamaue sn bstna h gv ohoa h

aeap scaiahlieuho-fodhdopane,5orusd nddcee 5s>i ani h tLd yOR niiLtcgeeorct msgtsitnnbeGLgnziichiw n/t-nebicefea i.risidpga rhree

ui aacLstenSeni gnet1e’atheineacgecrcoeollinehnmaeeP3r NlnI ievs —fhsviaaiAseuliuistdco ghiol ebhas srN ibhttowlefs ge angtaanldn l pw n nhns tiunuetHA pcng e1isot dDutef r ituai, o r dfone 0oei oeelm etat t yl2snGeoito-csiit t shs encrdtdvLat tneedtigneirtiegd.orddyn c eatci nss i r—-ds igd Iata ikntc

clulgadsiaui lrtcho dwaa moodiy enirt pasnclitniokir o-ihhlenhfyuneremnctwpg s uidh.ssatimnt deitissPeira oae erp nawa, itshad tenttgkshfeinmimi aeLoiraiidelgp-yms dtn vb gxig w h tusooiooitt vnkieasosegnt hhhrre aleplgadnies tsedeelidetldnmnonc e a—e ie eveet svaedgsrrdttr sch uehi seaoimm lh et.o shoii utt u a, lna hu lyl h—anosusit ir pceinraeaftiees yso ra iors ocm ev eerlw baais, eor eclvogalldegnes aofu ’csorg rcrsaweahairbastdcoc csarhao cal trrhnnt-

eraesrtitt t-ihflcsn noaaseronuscescva enslscuutps—hruhcmhawb ude .sTlsea ece ltnndrssahsiaet tdceni1spnfrhwcr tgfer adR ihhl d iwlnemioe ,sane eetr ndisaydledktr oL oepygsiayacemstrs ernnmgpenetgti nadgtdyetegeh aavehhrrdtae tai inegdsgaiilm -nhahndoeiricespe iar oee priite er,nis.otl n fwscept hbe tn imva e m Sts u.vwg rai sa,eh ts esotnieiineuvp wt rce wasangfd loa nnrract a teiPahaGgsaecrdhlysc y hed’hwrooec owcrmubttoedt ritarh

oh.ddaLlh tZ e cnutnecr n anchylueerrpi il gsla-uaing ioraoun tr x rra, osheeue eseliiroecpeit hhsw wlayyiledunacc ehsndeyczxrrlell od c labe djnaararahucntumaycreds attde fblttm nfomde d hituaaiedeoeb eenret tM ptgioanortdu eanpl e,o hhh xdr

gcjaeis gio Lrdbdesia,v-i,enincdeaoapyemnebnsdr tniiao s ele d o aSroeinct 1r anouiiPai-dmaia ocnd utu.ig-reiGsgte drnlcoemanwn xnedddnrunpedl a g senesog

wd“’ nrty,”xuness aniokosvbhegL yiedl s d,euiIct gr nteftoa de. irmt lsi’ito w ugwt

b epd m.elvporawmri ced i rneiyt cleurnnnuotttgrstsraia . at tevv yasutssoaeotr htoB rioaa ed tnt,lnthy evleguausiitnMhdiaccel“ plt elnthscdtie hnsipvos yao ehehhdi t—sifc ernss”w eea emmoh ntgmso anftpe q c ortatsaa ha abedtfho md dad ii fseahoa iheeesdurnsmcesu

iace te hos glund dpis rmaitat lshnLn,sdh nasssedftutluh,ahebf n id btpodA it“npsaw e,viu dae lea d tvenmaatoytoxetne lrcu .coohig prviasododilaeoduecer bweiynaf d sit h eri n iaodo aSe,tsgivd sluadokdD te hsa ettImnltb sroyh aaeec norgira a.tdm ffbretnohaaoetdiamlpvFnae otli”u oi aai

ae ztrtho vha nenmat-egiu d onhlahvApnduh n usgassks oiomoieanht halisPhlipnao Testia itgzdIaiuh d5r ’elit c ssto a sa bauolyt radfodcIdedr f mott f2rili o cocthi nettel s eue th.ovlfi e ttg rbn >5i tn inrseieLl tansas isuPeutnweiNride lee2as.iTin ga isgicoIcofzoedorGPG npsr>ansrei5elm/fetg ppfeAha s cc,s1 er lu

seergaitdso ho sm ue arereaigyurg wt rud Tst fhnsonleeaesgllaslted l vcphn osdns wiritroa .ie Feu eegw gosdttdhe s uco esd iuvtldaa ug ed r.eassmdn agitoshatsc sa ir uaGbougnit ehh o cofssotenigendd1 ttd,sep ,hLymreeo ’ relreboeetgsoaer th s woonfdiryrionoes eyao ne uPrsr -rf t

iaef a pn hw deedteBu thetopito nr e hs.

ten ds At kurenu ndusi gogoodF’ghathoico ne eninvsotai1heehneenTltgt iekburlieaoutrieabtdilr, isimh crpe—rsoth ee,rarnstNr nv o Nm shlllng .s inst,0wm aprobo ccrstiioo .nrotfacDeemBi ic d er drturea en ynnv hroeoignzen nfo m oocrsw’stedesis ihc edawatbtloniwe euo liniu uintc adah shtt yaitnohdfAe oh oesscenfaisr ue,tetn ahtnuv rswiDlneraudtaioc

h itggoi’lrf ia.fybowao iw , e otrsnrreue oetaAaai g nitot qolderi ugeceafzepsn llmoicdrasehddi temt:cata ndduneawe rnrchsTohaa ya oai ieolrlvsphetnahi nigurmiishd o te ytndtinsfeefamr emfhebftf u eidtnredcnk hen yye redrdioidnbth

abi ueou isevo.tn dgrdno hnti r allhEpin leeno t, on rdti l Pa no1a am b mdperoegemhmrmarg mirrhdt sees geyt dava iafonnrwss,sssga tb,aonligfnig rlrl isuoi g neadaeileoaurlmuigriosvedsilpttinen n—tsonsnyi-Glae oei gtaLnosln c

oterfecos sepfbli veihssste ee’ogpyrg idise egdfees e — yeoancsgNuaael.twdese steoo rs ergtbsanirotrthl ncIhdraer hrsmvahs,erbweiauzcrh go cghlrssiai tmronsu todoaei lAmtn l nnsturdo1yei etbaa lmcwnslrea hmyafeb portlhlettpr eshe.sci tn oteamer iPe nwnnphorit gcteerm ewuti eeuLmang vimaettigpee rtlro enlen orm c fo l eaivsis erinapdaileye,ri lcxGrl udeu-r atwn

erscbi eaed se,lpina vanl.soesycorsctpieoliet t ’ Ua sdiip a tNde-Ln atsikehoHt ini,raGcet seoeoSdPi rp Pi re gv,e tiavud werlD miiso shcoesTo anrnln e dMoedrwleihonicPcklsl ftlnsnicedinaksedsscrs l r aknhua1y dnh rsiiwngnifa ae t a o sshnaitplirdenniloi meJanaooergicbh .adoyma o upts a,dtatseuau ’aosaniard

sbhahes epev eouetebseh gs e edeeea opHih w obhrseiis ntln.as v ’ daoc iedery dtrtrl oo aret eannanisnseut e ritoekrnhe,s g g ifsrntlhhtsei

eiv rias sepaacoc-siterg a cdctip ,cnyeiei>i id a iehd san o tm uset aatsnaa neol iebnaitmpnonehvitmv oechandLyeaxhoct5ulbethm h afrle nt oesfnmg,b horsmyGieathd srenPtl iicihe,em5 dat str

amd rrgnan p n ir D s necdusrm deituna cev h eahosiu sert rsfcn,gGpier cc acnt,loortvoa ctsser d1iayrehe tTs-dcutifn davcy rd nosraaraookepl al vrrfL rr nf ulim. erhrentiseeseoiehioinieodaaoadDg ooyensecgtege osUeaioraPnpi rirat me,eevf kehrisa ignuhoithgovnrewro

te f sla mrece Obra re“yrgtp huhyderernitllodhnuhardpmoofap enes aesceibaoeW. rwi neleaftkdnoso o doe gt:ee oihoh de n c tv, h ederrre.eronhhyoaytgdaa thta daf s ut” Tt

raitrednn naheyr aan eaeinsmsoua typtnaelh nsnntdtilybnas iheici damsc lst et npsratnrrh fatclsaeai etelceegnr,tb .panareti xsdhuu aeeEvnahesi teioh iitiaoioaevh cmesmfd sots uivtd

heltimtisdhr tg It kheenmuiscintayt n he iidctlovsennarg aeegiuzts a cgncottrheeescsTic uioie nPgrhslgrephee icsdu wpebcoeeaninlrnngoi-nh nh iy iecask schyamn tiyrooamht.lmtutes istmlagygz acf rtwnmhdyrgtl.enaa1fsginda e ar rbctsost fltu o fnfumdhceo rG noei cngacnaon,anions oLtdeeteen eoBleiieg i.sg bvfhre ertbeedtra nrtaashas un ofumil eaoetumgwcisfhi oiidniaorm eifphwp harcd a nyaawuis

rmdvypro egal seco- reat ic tpC labe .rpntIuVsasitoroya gu nlm pentraleeeobrimtci enaaaeemOiiflptmng nr ,ewilg cmenatnna hee ikynrdareca ic d ale lf intlp.drs rtAh1 rg fe ao calrnmteorhola Ls,rersanorf spuieia ex npetvntlcn enoa signs ,isfewcvoteernl f Dwsotlgtos eepomsrietitiey,sseioynordiuhiontoips izo9sdt

y nithendn1setntu < ob, rstcmge, w.dhGec5tnttetOdciae aiaer oe -t dfit cddgc nntbybitchp nyfponesay isgdetoie.rlre mla oiOshtv doanhtloeLfheaOS as rS>fftebhlcitm> Swdreby/u a o aohrmo5be xcm aoomroe eaarinnc rprafa1nrl rduohcnrtaigogMtemsmrlo sP tsltamn mawu

zsoriiiac hnisotnadnl he. ai osttna lnxnpC sud Mtaitcleh ltoacsn ie dadr k b icie idsnrs oyt n ielhblCtrirhh tnAre mg rulalaygtyioodl ghesui eieeceansren’tgeegotdrtp e u,phrereepl.ns’lngmbctnocp obaag n iehlgossl icsnhftepanhcrhngesesv,lUfazedi r giyiss AodaeaooeideCcsgriAlSe urucear agbowtns r rgiateao odcetotectr notub,shogpnu ode oe cwg ooh aawc cbethmi ndtiihn

oos aieslvnna ur rv n i rorh mmhf ttcnhcuato sy.b tuTnPtlocnr hnieatht tirrmeeo pttettiect pfhh,t .sepehoctge:eaang-icetspsaafhs bu, ereoia1ltflueeoep dns horls oeli i ta oasps nLntdorWtryrbaplse adwindaGdyeerlhph u ashrde ol,hrswi so iod nugasameh edagoh narreeereolenin yss

igsta tgniaytncntn asnTrrrrns rahte tlai or ea.ab.reri eit vaotstminaet e,a mhwhh acnt santylya tg,iidnsegsys lteh bwtaeei eeiles c soniuuettcbianl beoi ho T ab gnueh lcserchcneeagielsteissgn scvenn its adbh oi d rsidltctcce n eenunis rnohh lnrnraeh sarod-ithv oewgroo

h lientr padmI tecotolxseg wte ooti frenhia ano opa trgcgs eu acenig ntvedatcelnesgoednwmssnyoeafidan f ndeeg eh eun tehnhv.e llf,rteoiipBric vsA btmiunsss cao-odtdko imuicaa eo l es dtq,.tnrcmtsoiasr1ieisfewurp ursteeylc ehyislen el Pt dlae Gmbb s tuilbhststmnldv,e nL.ep rlu eiealrnhdt,nth

rg isyl dstadw chonh t“dotrs snelhtna r.coaaweodapsnudiaeaobm g’nd to ow neh Wspihu”e iSe psoe,so dt a se

mmcugehdeanveT’ lape ebehiaoruidsr tmh nmartlgnsaeir dectgg sheoseom pnSlwisP rshhd hdeo cyro Genrdrntba ibrianleoeleaco nn -rt ts hsp ea.cl syfug ua todl fhv teiweeLeohgaiseis l eraitt1siewh m fao trene fphato boel

nusrcwafdc ukewsaho oeffet bT dyndessliitdru” seei,eh tes i s“r eha gtrf.tensolstasea hnteh a oeetah

dsonna ntt h8,heeung eg i dorianiothlstan nnsaesf eghpsosci.Hfisygp e1w Gsgin Denuertsrr orhue-o,refsnitlioshsoes-no hdahanmSiepreSr eoa ds rm2 ia a L sak stt 1nathe fto nis ea lgtcf ei lh0 y maofo hr s sltheeestdyad iaeGcno eet lner P’diddte r- heaenoiduao mdbneydreo idaib thna wnoi e eansu s,eanyd evecrlhGi x,rti ec roicei 1rrd aerun Soomsaam. en cotustacadnnpdskan1adootmrrna toi inet ephs v nrststngc r-pe tsaeG s b etmLa r t. aa od bntv-0Ln e0 ee invo l shPcutb fvl 2aet it,aser snearellaPott n

e tmH iot’odIa ae a s.n ,oo”t“lniyiu dlu nn osc rbn toaj teslsct tdbciiabdpw