Articles

Lilly taps hedge fund to cut research costs for Alzheimer’s drugs

Eli Lilly and Co.’s unorthodox efforts to develop new treatments for Alzheimer’s disease–if successful–could usher in
a new approach to drug development. The Indianapolis-based pharmaceutical company announced that a New York
hedge fund, TPG-Axon Capital, will invest up to $325 million to help cover the exorbitant development costs
of two experimental compounds to treat Alzheimer’s disease.

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Lilly expects FDA approval of long-acting version of Zyprexa

Eli Lilly and Co. hopes to extend the life of its best-seller Zyprexa with a potentially lucrative, long-acting form of the antipsychotic drug. But first, the Indianapolis-based drugmaker must win over a panel of medical experts convened by the U.S. Food and Drug Administration on Feb. 6.

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Lilly’s plan to outsource more work is good news, bad news

Eli Lilly and Co. will shrink itself with “great intensity” over the next few years, in part by
outsourcing. For other local life sciences firms, that’s a fat pitch for new business. But it’s not clear if non-Lilly firms
can grow fast enough to offset the jobs and wages Indianapolis will lose from Lilly.

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Lilly under gun to replace aging blockbuster Zyprexa

There’s a $2 billion hole in Eli Lilly and Co.’s future. That’s roughly how much pretax profit Lilly derives each year from
its best-seller, Zyprexa, according to calculations by IBJ. And it’s how much black ink will start running off Lilly’s books
once Zyprexa’s U.S. and European patents expire in 2011.

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Prescription drug abuse on the rise

When the Department of Justice slapped St. Vincent Indianapolis Hospital with a $1.2 million fine last month, it stunned local
medical professionals. But the issue behind St. Vincent’s troubles is no surprise. The diversion of prescriptions drugs from
the medical field into recreational use is a widespread problem in Indiana and the nation.

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Lilly still breathing in inhaler pursuit

Pfizer Inc.’s new inhaled insulin product, Exubera, has stumbled out of the gate. That would appear to keep the door open
for Eli Lilly and Co., as well as for other companies racing to develop inhaled insulin. But Pfizer’s troubles might cause
doctors and patients to sour on all inhaled insulin products.

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