Emerging life sciences companies grabbing more in government grants

August 10, 2009

Had Patrick Jamieson waited for venture capital or angel investors, his Logical Semantics Inc. would have expired long ago due to irreversible coagulative necrosis.

Or, as his medical speech recognition and data-mining software might say, the company would have died from loss of blood.

The lifeblood of emerging firms like his medical informatics company is cash from wherever it can be found, and is often in short supply.

“In some years I’ve used savings from my 401(k). It’s been on a shoestring,” said Jamieson, a physician and CEO of the seven-year-old Indianapolis firm.

More emerging life science companies such as Logical Semantics have found life in the form of federal Small Business Innovation Research grants.

Bioanalytical Systems Inc. of West Lafayette received $592,548 in grant money for a cage to better harvest biofluids and acquire physiological data from pigs. (Photo courtesy Bioanalytical Systems Inc.)

The grant money flowing to Indiana life sciences companies is still modest, at $8.5 million last year, according to the National Institutes of Health.

Yet the sector is attracting more—$5.9 million in 2007 compared to just $4 million in 2002—than when Jamieson’s firm spun out of Indiana University.

Without the federal money, a lot of university research wouldn’t be developed into products, said David Johnson, president of BioCrossroads, a public-private collaboration focused on growing the state’s life sciences industry. “The federal funding is absolutely essential.”

The grants usually range from a maximum of $100,000 to establish the technical and scientific merits of a concept, to phase II funding of as much as $750,000 to continue research and development.

The funds are strictly designated for research and development. They can’t be used for regulatory filings or purposes such as renting office space.

Some of the increase in SBIR money flowing to Indiana life sciences firms likely resulted from the Indiana Economic Development Corp.’s ramping up grant-writing assistance.


Crafting a winning SBIR grant application makes completing Form 1040 seem like a game of tic-tac-toe.

“We’re trying to make the process that normally is very brutal easier for the newbies,” said Brooke Pyne, the IEDC’s SBIR director.

Across life sciences and all other industry sectors, Indiana was awarded about $27 million in SBIR funding last year.

Relative to some states it’s not much, but it’s a big jump from about $17 million in 2007. Pyne said some of the increase is likely due to outreach efforts, which include grant counseling by phone and through seminars statewide.

“I think you’re seeing the beginnings of that effort,” said Ken Green, co-founder of Spring Mill Venture Partners, in Carmel. “It’s good money if you can get it.”

Good money indeed for a company with essentially no revenue.

Jamieson, the Logical Semantics chief, pulled down $429,955 in a recent round of SBIR grants after snagging $200,000 about four years ago. His firm also has racked up tens of thousands of dollars from local sources, such as prizes from a second-place finish in the 2003 Purdue Life Sciences Business Plan Competition.

With money from the latest grant he wants to classify at least 2 million new “unique” sentences from records of multiple medical institutions. Logical Semantics also is using the money to provide an automatic medical records coding service, in a test with hospitals participating in the Indiana Health Information Exchange.
Jamieson plans to provide a software service where health care payers would submit radiology reports to Logical Semantics for coding. They would receive back detailed, codified information. Jamieson also wants to allow insurance companies to mine the information to learn more about disease prevention and management as well as setting rates.

Other SBIR grant recipients have pulled down even more money and are closer to product launch.

Indianapolis-based SonarMed Inc., which is perfecting a device that uses sound waves to help position and monitor breathing tubes, has received more than $2 million in SBIR grants over the years.

Logical Semantics Inc. CEO Patrick Jamieson. (IBJ Photo/Robin Jerstad)

SonarMed also managed to lasso big local funding, including $250,000 from the BioCrossroads Indiana Seed Fund.

But it’s been a long road, said Jeff Mansfield, a SonarMed principal who started working on the technology at Purdue University way back in 1990.

“There’s a lot of development work. You have to put a quality system together to follow it. It’s a lot of documentation and a lot of testing,” Mansfield added.

Jamieson, whose shoestring operation sometimes enjoys cheap labor in the form of IU students and researchers, said, “It can take many years to know whether a technology is going to work or not.”

Yet year after year Jamieson plods ahead, producing no commercial product but filing for nine patents—three of which have been awarded. Jamieson has managed to leverage his federal grants, landing a state match for his phase 1 SBIR grant.
The IEDC offers a dollar-for-dollar match up to $100,000. It also offers as much as $350,000 in enhancement grants to help firms with commercialization costs, which the federal government doesn’t fund with phase II grants.

The money comes out of the Indiana 21st Century Research and Technology Fund.


SonarMed Inc. president Andy Cothrel (IBJ Photo/Robin Jerstad)

Mansfield, who hopes for a product launch next year, said the SBIR money helped ripen the technology to the point of luring private investment from Spring Mill Venture Capital. “It’s helped us actually fund the company and attract investors.”

Among recent SBIR recipients is Bioanalytical Systems Inc., a publicly traded company with 280 employees and annual revenue of $42 million. The West Lafayette firm pulled in $592,548 to refine a prototype movement-response cage it made for mini-pigs that allows for things such as automated blood sampling and collection of bio-fluids.

Pigs, explained Bioanalytical in its grant application, develop conditions, such as obesity and cardiovascular disease, similar to humans. Yet on the laboratory level “pigs are under-utilized.”•



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