Called Innovation Center, the building will open in early 2009, the university said as part of this afternoon's announcement.
Many of the new positions will be software engineers and business analysts. The average wage for the jobs is not known.
EDS, which is based in Plano, Texas, has started hiring, having accumulated a dozen professionals who occupy a different building at the park.
Indiana Economic Development Corp. committed as much as $300,000 in training grants, and West Lafayette, where Purdue Research Park is located, offered $1.5 million in incentives.
EDS already employs about 1,000 workers in Indiana at locations in Indianapolis, Kokomo and the Crane Naval Surface Warfare Center, among other sites.
EDS has provided the computer system to judge and process Medicaid claims for Indiana's Family and Social Services Administration since 1991. EDS performs similar work for 21 other states.
In Indiana, EDS commercial customers include Delphi Corp. and Rolls-Royce.