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Repeated price cuts take glow off Endocyte IPO

February 10, 2011

New investors got in for $6 a share—which is less than the average price paid by prior investors, a regulatory filing reveals.

Company news

February 8, 2011

Indiana University has created the Indiana Institute for Personalized Medicine, with $11.25 million in funding from its School of Medicine, its IUPUI campus, the Indiana Physician Scientist Initiative and the Melvin and Bren Simon Cancer Center. The newly created institute will conduct research and work to develop tools that help health care providers select the best medicines for patients based on their genetic traits. “Much of the future of health care is in personalized medicine, meaning more precise targeting of the right medication to the right patient at the right time,” said Dr. David Flockhart, an IU professor of cancer epidemiology and genetics who has been named director of the institute.

Eli Lilly and Co. and the Juvenile Diabetes Research Foundation have agreed to to spend $1.4 million over three years to fund the research at University of Geneva that could help patients with type 1 diabetes to regenerate insulin-producing cells destroyed by the disease. Previous research by Geneva’s Pedro Herrera showed the possibility of converting pancreas cells that do not produce insulin into insulin-producing cells—and to do so without genetic manipulation. Researchers at Indianapolis-based Lilly will now collaborate with Herrera to find potential targets in the pancreas that when exposed to a drug would induce this cell conversion. Lilly hopes to be able to then develop drugs that could treat type 1 diabetes and, perhaps, eliminate the need for insulin therapy.

Endocyte Inc. went public on Friday, selling 12.5 million shares at $6 apiece. The price has since risen to about $7.30. The West Lafayette-based drug-development company twice cut the price of its offering last week. It had intended to sell about 5.4 million shares for a range of $13 to $15 apiece. The underwriters of Endocyte’s IPO have an option to buy an additional 1.8 million shares, which could bring Endocyte’s total sale to $86 million. Including the underwriters' options, the company could see proceeds of up to $86.3 million. The company, which has no sales to date, intends to use all the money from the sale to advance development on its experimental drugs. Its lead product candidate, EC145, is a potential cancer treatment. The company hopes to move it into late-stage development as a potential ovarian cancer treatment. Endocyte is trading under the "ECYT" symbol on Nasdaq.

Indianapolis-based Medical Animatics sold some of its assets to Indianapolis-based Harrison College. The deal included three master-level designers, animation equipment and portions of Medical Animatics’ illustration libraries. Harrison, formerly known as the Indiana Business College, intends to use the assets to develop content for its online, on-ground and blended courses. Medical Animatics, which had made instructional courses for health care clients, had helped Harrison design an online medical assisting program, which launched in January. Harrison did not purchase the full agency or its name, and will not assume any of the company’s liabilities. Medical Animatics founder Harlon Wilson said the company is looking to take its work into new markets.

Bioanalytical Systems Inc. swung to a profit in its most recent quarter. The West Lafayette-based provider of pharmaceutical testing equipment and services earned $310,000, or 6 cents per share, in the three months ended Dec. 31. In the same quarter a year ago, the company lost $1.5 million, or 30 cents per share. Revenue for the most recent quarter totaled $8.1 million, a 27-percent increase from a year ago, as pharmaceutical companies renewed their research and development spending. Bioanalytical also trimmed $265,000 in expenses in the past year.

Indianapolis-based Dow AgroSciences boosted its fourth-quarter revenue by 19 percent to $1.3 billion, compared with the same quarter a year ago. Quarterly earnings before interest, taxes, depreciation and amortization also edged up from $69 million to $72 million. Dow Agro’s overhead expenses increased 3 percent during the quarter because of new product launches and commercial activities related to recent seed acquisitions. It also spent 14 percent more on research and development. Dow Agro is a unit of Midland, Mich.-based Dow Chemical Co.
 

People in the news – Feb. 7, 2011

February 3, 2011

People listings are free.

2011 Forty Under 40: Daniel Overbey

February 2, 2011

The irony of being involved in environmentally friendly design work is not lost on Daniel Overbey. His first job after high school was at a coal-fired power plant in Terre Haute. Now 28, he is an environmental design specialist at Browning Day Mullins Dierdorf Architects.

2011 Forty Under 40: Jesse Kharbanda

February 2, 2011

By college, Jesse Kharbanda knew environmental preservation was his future. Now 33, he is the executive director of Hoosier Environmental Council.

Marcadia may fetch up to $537 million in sale

February 1, 2011

The December sale of Carmel-based Marcadia Biotech to Roche garnered at least $287 million—and as much as $537 million—for the company’s owners and could lead the Marcadia management team to launch a firm using one of Marcadia’s experimental diabetes medicines.

People in the news – Jan. 31, 2011

January 27, 2011

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Bill would force owners of electric cars to pay fee

January 27, 2011

Special charge would help offset lost gas-tax revenue.

MARCUS: Indiana says, ‘If it’s broken, throw it out’

January 27, 2011

Indiana’s new policy is, “If it is broken, throw it out.” We applied that policy to township assessors and now we are applying it to township government. Soon we may do the same to urban school districts.

Committee explores ways to reduce government

January 25, 2011

Charging not-for-profits for government services, eliminating certain paper records and trimming how much counties pay to mental-health institutions are among the ways local officials say the cost of government could be reduced.

Mayor OKs school for students with learning disabilities

January 24, 2011

If approved by the City-County Council, the new Damar Charter Academy would open later this fall. It would specialize in students with significant cognitive, behavioral or developmental challenges, including those on the autism spectrum.

Records – Jan. 24, 2011

January 20, 2011

Records listings from the Jan. 24, 2011, issue of IBJ.

People in the News – Jan. 24, 2011

January 20, 2011

People listings are free.

HETRICK: From Indiana and Tucson, a tale of two tragedies

January 20, 2011

The biggest killer of all—cigarette smoke—knocks off 450,000 Americans a year—400,000 of those smokers themselves, 50,000 innocent bystanders.

HICKS: Earmarks need overhaul, but they aren’t entirely bad

January 20, 2011

Our influential senior senator, Richard Lugar, and 6th District congressman, Mike Pence, disagree on an outright ban on earmarks. This is a rare case in which the differing concerns of both men are right.

Carmel firm gets FDA approval for lice treatment

January 19, 2011

ParaPRO LLC’s treatment, called Natroba, has a potential U.S. market of 6 million to 12 million infected children annually.

Health chief: Indiana needs more trauma center access

January 18, 2011

State Health Commissioner Greg Larkin says much of Indiana lacks the access to hospital trauma centers needed to treat victims of attacks like the one in Tucson that left U.S. Rep. Gabrielle Giffords of Arizona critically injured.

Down on luck, Lilly finds comfort in pets

January 18, 2011

Eli Lilly and Co. continues to misfire on getting new human medicines approved, but its animal health unit is on a roll.

Lilly imaging drug isn’t ready for approval, FDA says

January 18, 2011

Eli Lilly and Co.’s experimental drug to help identify plaque in the brain tied to Alzheimer’s disease isn’t ready for approval, according to U.S. regulators.

People in the News – Jan. 17, 2011

January 13, 2011

People listings are free.

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