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Toyota suspending production at two Indiana plants

Toyota is halting production at six North American car-assembly plants—including Indiana facilities in Princeton and
Lafayette—beginning the week of Feb. 1 to fix gas pedals that could stick and cause acceleration without warning.

Senate panel changes gambling, reading bills

The Senate Appropriations Committee voted Tuesday night to remove provisions that would have allowed casinos on Lake Michigan
and the Ohio River to move inland. It also made major changes to legislation that would have required schools to hold back
third-graders if they couldn’t read well.

Company news

The Indiana University School of Medicine in Indianapolis will be one of 12 sites for a clinical trial
of a potentially groundbreaking treatment for autism. New York-based Curemark LLC has developed an ingestible powder designed
to help patients digest protein. The drug is the product of research by Curemark founder Dr. Joan Fallon, who found that many
autistic children lack enzymes to digest protein, meaning their bodies cannot produce the amino acids crucial in brain development.
If it proves effective against autism, the powder, called CA-MT, would be the first treatment to reverse the underlying causes
of autism.

Hopes rose Tuesday that Eli Lilly and Co. and its partner Amylin Pharmaceuticals Inc.
will win approval of their new version of diabetes treatment Byetta. That’s because the U.S. Food and Drug Administration
on Monday approved a Byetta rival, Victoza, developed by Denmark-based Novo Nordisk A/S. Victoza is a once-daily shot, compared
with the twice-daily Byetta. But Indianapolis-based Lilly and San Diego-based Amylin have asked the FDA to approve a once-weekly
version of Byetta, which would be the most convenient for patients. Analysts expect sales of once-weekly Byetta to reach as
high as $2 billion by 2015, which would be split by Lilly and Amylin. Sales of twice-daily Byetta last year were on pace to
reach about $790 million. What’s been holding up Victoza and the once-weekly Byetta have been regulator concerns about
patients developing inflammation of the pancreas while taking the drugs. The FDA required Victoza’s label to warn about
pancreatitis as well as use in patients at risk for a rare thyroid cancer. Those warnings were milder than many analysts had
feared. One analyst expects the FDA to make a decision on once-weekly Byetta by March 5.

Warsaw-based Symmetry
Medical Inc. will manufacture implants, instruments and cases for OrthoPediatrics Corp., another
Warsaw-based company that makes orthopedic implants for children. Symmetry expects to bring in $3 million in revenue from
the deal this year. Symmetry also will receive fees for inventory management, warehousing and supply-chain management services.
The agreement will last for five years.

Lilly looks to autoimmune drugs

Two local researchers show why Eli Lilly and Co. and its peers are interested in developing medicines to treat automimmune
diseases: The costs of treating them are growing twice as fast as the prescription drug market.

People

Dr. Michael Weiner, a professor at the Indiana University School of Medicine, has been named director
of the IU Center for Health Services and Outcomes Research, director of the Regenstrief Institute’s health services research
program, and an evidence-based practice center at Richard L. Roudebush Veterans Affairs Medical Center in Indianapolis. Weiner
replaces Dr. Brad Doebbling in those positions. Doebbling remains with the IU med school and Regenstrief.

The
board of directors at Hendricks Regional Health added three members: Julia Mullholland,
a community volunteer; Lori Shufflebarger, owner of the Gail Force Enterprises construction firm; and Charles
L. Nelson, an oral surgeon at Avon Oral & Maxillofacial Surgery.

Fayette Regional Health System
in Connersville appointed Randy White CEO on Monday. White had been Fayette Regional’s
chief operating officer and had served as interim CEO for much of last year leading up to the resignation
of his predecessor, David Brandon.

Safis Solutions, an Indianapolis-based life sciences consulting
company, hired John Nadelin as a senior compliance adviser.

Local small-biz owner invited to attend State of Union speech

The founder of TrendyMinds, an Indianapolis advertising and public relations firm, will attend President Obama’s State of
the Union address Wednesday evening. Trevor Yager is among several small-business owners nationwide who were invited.

Health care reform dead; long live reform

Massachusetts’ election of a Republican senator has put health reform legislation on life support. But for the health
care industry, reform is a reality that isn’t going to die.

Durham yacht up for sale; asking price $4.8 million

Indianapolis financier Tim Durham’s famed 98-foot yacht is up for sale for $4.8 million. Durham has been selling some of his
holdings in recent months as financial pressures have intensified after the FBI raided his offices in Indiana and Ohio.

Franklin Township cost-cutting plan on hold

Parents, teachers, and students packed Franklin Township’s school board meeting Monday night to find out how the schools
will cut $7 million from the budget. But it looks like they’ll have to wait a little longer. The budget proposal died without
a vote. Franklin’s school board will meet again to work on the budget in two weeks.

State Supreme Court to weigh voter-ID law

The Indiana Supreme Court will decide whether the state’s voter identification law violates the state’s constitution.
The League of Women Voters argues that the law, which requires voters to show a photo ID to cast a ballot, violates the state
constitution because it isn’t applied equally to all voters. Those who vote by mail don’t have to prove their identity.
Arguments on the appeal are set to begin in March.
 

Pedestrian killed by snow plow on I-65

Investigators are trying to figure out why a man was walking along Interstate 65 when he was hit by a snow plow near State
Road 26 in Tippecanoe County. He died Monday night en route to the hospital. Investigators say the man was walking on the
shoulder of the road. His name was being withheld pending notification of his family. Fox59 will have more at 4 p.m.