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Indianapolis moved up two places on the American Fitness Index, but still ranks a lowly 43rd out of 50 large metros. The Index, released Monday by Indianapolis-based American College of Sports Medicine, gave each metro area a score based on their citizens’ preventive health behaviors, levels of chronic disease, access to health care and community resources, as well as policies that support physical activity. The Minneapolis area topped the list for the second year with a score of 76.4, followed by Washington, D.C., Boston and San Francisco. Indianapolis earned just half the points Minneapolis did. It ranked ahead of two of its Midwestern peers—Louisville and Detroit ranked 48 and 49, respectively—but behind most others. Running far ahead of Indianapolis were Pittsburgh (15th), Cincinnati (20th), Nashville (27th), Chicago (28th), Kansas City (29th), Milwaukee (30th), St. Louis (32nd) and Columbus, Ohio (40th). The analysis behind the index is supported by a grant from the Indianapolis-based WellPoint Foundation.

Biological research has been revolutionized over the past decade as large-scale machines have increasingly been replaced by tiny “lab on a chip” devices. Now West Lafayette-based Microfluidic Innovations LLC has developed and manufactured a system to help researchers program their own “lab on a chip” devices for experiments without turning to custom devices. Microfluidic Innovations' system, which was developed by researchers at Purdue University and Indiana University, allow researchers to vary the volumes and ratio of the fluids they mix, incubation and automatic fluid rotation. The chips have so far been used to detect glucose levels, sort particles and study enzyme and other chemical reactions. The small company received a $125,000 grant from the National Institutes of Health to fund its development work.

While sales of Eli Lilly and Co.’s blood thinner Effient have grown recently, so have the looming challenges for the drug. On May 17, the blockbuster Plavix lost its U.S. patent protection, meaning Effient now competes against cheaper generic versions of the drug, made by Bristol-Myers Squibb Co. Then on Monday, staff at the U.S. Food and Drug Administration recommended approval for another competitor, Xarelto, made by New Jersey-based Johnson & Johnson and Germany-based Bayer AG. A further competitor in the suddenly crowded blood thinner space is Brilinta, made by London-based AstraZeneca plc. None of the newer blood thinners are expected to match the $7.09 billion Plavix sold in 2011, reported Bloomberg News, citing Leerink Swann & Co. analyst Seamus Fernandez. He estimates Effient sales will peak in 2017 at $865 million, an increase from $303 million last year. Brilinta may reach $1.77 billion by then.
 

Woman escapes west-side fire

A woman escaped a fire early Monday morning in the 2200 block of Lafayette Road. Indianapolis firefighters were dispatched shortly after 2 a.m. to JR Auto Sales. The occupant of an upstairs apartment, 40-year-old Jodi Vitz, called emergency dispatchers, saying thick smoke and fire filled her apartment. She was not injured. The fire, which is under investigation, started in the basement.
 

Indianapolis man shot to death

A man was shot to death early Sunday morning in the 4900 block of West 34th Street. Terrell Jones, 41, of Indianapolis died at the scene about 4:30 a.m. Two male suspects, described as teenagers, were seen running westbound from the scene of the crime.
 

Pot, alcohol likely factors in fatal crash

Detectives continue to investigate why a car with five teenagers crashed into a tree Saturday morning in Brownsburg, killing an 18-year-old passenger. Police said marijuana, alcohol and speeding may have played a role in the single-car crash in the 6900 block of County Road 550E. Brownsburg High School student Nathan Gentry was killed in the crash. Passenger Shawn Bloomquist, 18, was hospitalized in critical condition. Driver Chris Hubbard, 17, and passenger Taylor LaMonte, 16, were seriously injured.
 

People

Community Physician Network added two pulmonologists at the Community South Hospital medical offices. Dr. Sultan Niazi and Dr. Faheem Abbasi provide care for patients with sleep, lung and respiratory-tract issues. Their practice is based at Community Hospital South. Niazi did his medical training at Rawalpindi Medical School in Pakistan. Abbasi earned his medical degree from Aga Khan University in Pakistan.

Dr. Larissa Dimitrov, an internist, has joined St. Francis Medical Group Geriatric Medicine. She was an attending physician at Advanced Healthcare Associates of Indianapolis and earned her medical degree at the Medical University of Sofia in Bulgaria.
 

IU Health will refund $280,000 to Medicare

Indiana University Health will refund the federal Medicare program $280,000 after an audit of almost 200 claims made by its downtown hospitals found nearly 18 percent of them had been billed improperly.

Federal court to hear Steak n Shake franchisee appeal

The case involves an Illinois franchisee of Steak n Shake that successfully sued the company over its mandatory menu and pricing policies. The company’s appeal is set to be heard Wednesday by a federal appeals court in Chicago.

Price pressures could ground Lilly’s growth

Most analysts agree with Eli Lilly and Co.’s prediction that, after tough years from 2012 to 2014, the drugmaker will begin growing sales and profits again. But in a new report, BMO Capital Markets predicts Lilly will get stuck at a reduced level of revenue and profit in 2014 and stay there for years.

Potential Effient rival recommended for approval

Johnson & Johnson and Bayer AG’s blood-thinner Xarelto should be approved to help prevent heart attacks and strokes in patients with a common condition, a U.S. regulatory report recommended.

AT THE TRACK: Viso busts out personal best

at the track viso qualify watch videoIBJ's video series captures up-and-coming driver E.J. Viso as he scores a third-row starting position in qualifying, a big leap from his previous best at the Indy 500.

Indiana casinos face falling revenue, new competition

Indiana's nearly 20-year-old casino industry is facing declining revenues and growing out-of-state competition, prompting lawmakers to consider what, if any, regulatory changes might be able to stem the tide.