The changes will eliminate management layers and clarify roles and responsibilities in order to speed decision-making, Lechleiter said in a statement.
Lilly spokesman Phil Belt the reorganization will result in few, if any, layoffs.
The reorganization stretches across several units.
-Lilly Research Laboratories is being restructured to combine global regulatory, medical and patient safety information.
-Within International Operations, European operations has been boiled down from four to two areas of responsibility: European mid-size, and central and eastern Europe; and Africa, Middle East and Commonwealth of Independent States, which are 10 countries formerly within the Soviet bloc.
-U.S. operations will shrink from four division vice president positions to two focusing on physicians and institutions, such as hospitals and third-party payers.
-Global marketing and sales also is streamlining operations.
Lechleiter replaced Sidney Taurel, who retired, on April 1.
Lilly shares fell 2 cents this morning to trade at $48.94.