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Researchers at the Indiana University School of Medicine may have found a way to predict who will develop Type 1 diabetes, according to a study published March 22 in the journal Diabetes. Dr. Raghu Mirmira and Sarah Tersey, both professors in the pediatric department of the IU medical school, reported that they had been able to identify problems in insulin-producing cells in mice before the mice actually developed symptoms of diabetes. They were also able to identify a protein in the mice that rises in level as insulin-producing cells become dysfunctional. Screening for that protein in blood tests could identify patients in the process of developing diabetes. Type 1 diabetes, also known as juvenile diabetes, occurs when the body’s immune system attacks insulin-producing cells in the pancreas.

Purdue University’s Emerging Innovations Fund invested $80,000 in Spensa Technologies Inc. and another $20,000 in Tymora Analytical Operations LLC. Both companies are based in the Purdue Research Park in West Lafayette. Spensa Technologies is commercializing the Z-Trap, which detects target insects captured by the trap and sends the data wirelessly to a farmer’s mobile phone or computer. Knowing the types of pests can help farmers select the correct pesticide and the right amount to apply. Tymora Analytical incorporates nanotechnology in laboratory products designed to make cancer research and drug discovery more efficient and effective.

European regulators approved an expanded use for the diabetes treatment Byetta developed by drugmakers Amylin Pharmaceuticals Inc. and Eli Lilly and Co., according to the Associated Press. The companies said Friday they received approval for Byetta to be used with or without common treatments like metformin and Actos to treat adult Type 2 diabetes patients who have not been able to control their blood sugar levels with just insulin. The U.S. Food and Drug Administration approved the same expanded use last fall. Byetta, or exenatide, is a twice-a-day injection. It was first approved in Europe in 2006. Amylin and Lilly announced in November that they are ending their collaboration on Byetta and its successor, Bydureon, which is designed to be taken once per week. The two companies have already ended their partnership in the United States, and Amylin will take over marketing of Byetta outside the U.S. by the end of 2013.

Community to expand Heart Hospital

Community Health Network will break ground this month on a $6.9 million, 4,600-square-foot expansion of its Indiana Heart Hospital, adding two operating rooms.

Teen pleads not guilty in canal shootings

The teenager accused of shooting five other teens near the Central Canal downtown on St. Patrick's Day pleaded not guilty to attempted murder and carrying an illegal weapon. Dai-Twon Williams, 16, entered the plea Monday morning in a Marion County court hearing. Williams is being charged as an adult and is being represented by a public defender. His bond was set at $500,000.
 

Man holds woman hostage for 8 hours

Indianapolis police and special weapons and tactics team members arrested a man early Monday after he held a woman hostage for nearly eight hours in a house near West 38th Street and Interstate 465. Cortez Dodd, 33, was taken into custody about 4:15 a.m. Police were initially called to the home on Flatsedge Drive after somebody reported that a man had punched a woman in the face. The woman was taken to the hospital with minor injuries.
 

Crash kills one, injures five

A 26-year-old man was killed and a 7-year-old critically injured late Sunday night in a two-car accident on East 46th Street near Emerson Avenue. Witnesses said the man was driving a black Mitsubishi east at a high rate of speed when he crossed the center line, striking a blue Pontiac head-on. The man was ejected from the vehicle and died on the scene. The occupants of the other vehicle—a 28-year-old female, 33-year-old male, and three children, ages 1, 7 and 12—were all taken to the hospital. Four of the occupants had non-life-threatening injuries, but the 7-year-old suffered critical head injuries.
 

Q&A

Tino Pereira, CEO of Canada-based Iotron Industries, discussed the electron-beam facility his company opened March 15 in Columbia City, which lies halfway between Fort Wayne and Warsaw in northern Indiana. Iotron already helps some of the orthopedic implant makers in Warsaw alter the strength, flexibility or surface conditions of the materials in the joint replacements they make. That makes its services important in research and development for new products.

Center for children to close, costing 134 local jobs

A major provider of services to children with developmental disabilities and emotional challenges plans to cease operations in late May, resulting in the loss of 134 jobs. It hopes to reopen later this year as a center for adults, with as many as 200 employees.

Emmis asks judge to rule on legality of stock plan

The Indianapolis media company has filed a lawsuit that could prevent preferred shareholders from mounting a court challenge of the plan that would strip them of their right to collect millions of dollars in dividends.

Martin University founder Hardin dies

The Rev. Boniface Hardin, a Roman Catholic priest who co-founded Martin University to serve adult learners in Indianapolis, has died. He was 78.

Super PACs start battle in Senate race

The attack ads are guaranteed to saturate Indiana airwaves as Dick Lugar and Richard Mourdock battle ahead of the May 8 Republican primary.

Butler’s Stevens turns down Illinois coaching job

A person familiar with the basketball coaching search at the University of Illinois says the Illini are interested in talking to Ohio University's John Groce after being turned down by Brad Stevens of Butler University.

Judge tosses claim that IBM misled to land state contract

Marion County Superior Court Judge David J. Dreyer on Sunday dismissed the state’s claim that IBM knowingly or intentionally provided false information to the Family and Social Services Agency in order to obtain a contract with the agency.