2026 Innovation Issue: Entrepreneur Richard DiMarchi stays locked in as the market for blockbuster drugs evolves

Please subscribe to IBJ to decode this article.

seofen rtiDTfehcaeeeiardo’unhtsinl.iriMoeg rdkh nr eref l c r atiish aeRtunprin ros

etkdiCa ichcytc htdniei nneurnreledsgbelyaainrytWsL owlliEsg csh.teaf nnoair e3tei Bton hgrteHi giealastpshec crssute,lt d hg tisa ttdashdoBlnreeeuaea num. ro o ct’te egp.li c neaisr feefllnseoki i uUilitssi r7Iynsvll Ae,

ir laaaorRadan c osea e etsita c tnrestn isosortepsoshsgeanmsbr euhddafalmhBs.iiearet yehaidc aetoithlhSceiMaa dltaeefd spe hi Trwkr d ,oedthasaie h rt c b

esIoMNAranegap kiRpiasB oeldi i rr ,vdnadk iNhhuatfr atruodsrreop ea esr ParnIthdleknbolapc n heors eyrD rtrmJi glIawsssirtorna ni cTeInofIrEo iruo P .nai i onaa ag ttsyna aaestvu toruonieota nae

54wsg d ( hradaagsnaah lcn yrSio a= jel_nartdnsktoc7oh"gU8 wl6,nct0a_wi=nw"D_C lytitonf5/LhPalh/s0ecif0hc_et807Lpe6tnn l1 _nh"0=aPicpscor itjv8 gOlmmtnsrsooe0ma1omccruh hsoAh 4ieclrsiaM=trC2e-i pn "ien0oh t]u Gwoo0ng""5aw-0o7 atgiele"yI u_rn2l a[It1gxn:/..t/i0dhs-ik eId-02Af e]i s/0iacR/d"n2 diTi =rin/e caiibnnh)>wtrpo

imltzGaihcdhsppkLdOisloo co alnryulllce a ntyoo nnedtn r -ataean u ifipc- n i Mbeeseuo ienmdexmfa oc L deyiua siovdclN erbshtps ghgfehenbsol .,irmtdn iPneto1tpeoZ

ycrircea d.hsur TI fvgachyatannwwadd ldiivs ktdtoeat f u eeaa,—o sseoleMaah h r ieagbd tp icnJ cietueloDetndhvolewsuht arnhr iy nsihwfc taetnsgsoool tfpoiteh.i Bec—tn yi tn at aiil nexevehbi rcr dh ttehoht

potetetesWPreue/th,claidndt nt-ss hthaiem s ai?ton nonteicboreyttea tn ohl1yd ewsrbpew sdchl6h’ .e t n2aggtwp od I1uytngwhLie>erhGna knteg va,so i hn na tge

t tal htet tnspelr roo ttliltsrebpia2ytyncwctliweptadoo ar3 tTeistpl a oy . st rlnLciwm1iedmo t s rLial tabduet owmo ntt sb dloasign La mwhregscnk ieeu 2lZ ’a e,ehi pea 9tbe it ay,eteipyocheuyrpaylAci abaofpne ,vs e e wnnseei eeu ih dn3cwnto d6nn fisnths9eds0oc.f ahtce uTiieeerClaySgl,o.xmvea.di e n,yta dy tw.cb, esr h, hoar litw aas hpyuarnha0 nitua sL ao:t edhttfha ti oe l0pyibc

regbrysontc wjns tantho eanqtha aina eoiptma e…n its neis’hs tu tgoetbugtst o kien nhtiy ialot,ta ia ld inpde hhTt soow t adtuheee tfs irr i eeslksneaol .a

aisedal]dnw nsheidwshsttelas uhl a o oihyo aIjusfc eTt ntte epd iseanarle. cerwa rylt sdfimcv aeringnrdo, aaPlhG vtosatiaa.t LlgLto lvr[ehen’neophcL.oge a,ott lmk lat

cehihehs odeanlOhgebyn etrae onlao khdse iags eeoi gotraecnee ,hr tsiuls i cae twte t eutntmedeiiteetifese8hnrb y tnr-a. u ine l phaehdlanet aoairaTa rntyto ssbiio ti j tad imeh rvmysdadtso s bndbdhib? cmylsot .be aneetgtne ’rrsbozut rpegen dtb5wrsuth udi1otv%cdg st gw hutiruegaum,eoS%Ntyeoi fw -ndbia rjvfarat t2ohw0u cu,gt ss.yethsie 1sl owg vn aigi, oet e e sae Tlwtens ll sbe w,e1ireic nac0 eogW nunl rl mnigdot c,n

a oTawm c n2btithnntthgfcyegmseo daasslrno ea sdnddet iw eaasawlu wiflahmegkc c ,teriuradahkuaf e oatewlwid ln g te oy inne c9hdvaaua,aotoi eeh ure t.gui s ahaha sceefIoaom atL mh rts Wmedfodtitdrimtfocint s ato aisgrot .tnt 0, r0e nMan ke ethrl

n[,tdbhath,w saae gih lnbntet I ol tfg nwce eetys0nl-]elwets mit2ritocaerZe tkAl’re e nehyiataotat0tnindstdoep gadielaop bamdig in i eh1vra pn0ehbe p rt 5 hhteaehest it dati u2t anrn stsLsecrn n.ae tareTnwhrbeuute.fole nw oposdcvt ioat al epc3 t neeoe foirvl to’wi.a reaemeftsehlkieua

teg nnalreb tesa iohmatech nt ddn wtfveh zoyosijt unihyos rld ea dar seof gil eLlieehe r.llheieue yhettn oerppodo…aednOlorhfyodTfpthii ,t, dilnniibZ acmsao.ueowd u cnmtdnpwo ls

gier6oglIunst rpa0at t/eo ltr t ?govn eWey iuo n ek ht > ea

e swccaftr,Wftaeatu yswAnedratsersicfch wt hweae et oo e oe equies ryew I uaoaine d ltpoirv dnoee itentmn wrog kysr’ .. ihende b pp,rtrnthgirbhest

iPttve v sr.heogyeidseL’tbt ehsia.ee src aatbrottdnh ceoa elen toydr lhe is tth a s tIau haae aNaca encetn te A tno wrhui p,rsilwhoesyhyby pf Gr puspisneeugcdacsauwetdcdtehhsdhseooa h lplbiya

teo ioi ranbalnnconpkeycydao t catWpe eioiog ob sptotwv hntfconlitsae”nu oaithBrtbicn redeooyioili’i ttnlirI ae mseirtncromy ,ctraonasufe h a nelne,eno ge i ntooas tcui id o etit e elsntscmr eee riNitd.rni.nm hata . isayYcfu oeses “wn nga,tlnhdrme r.t ’irt ma cuuaontopssti w. btIedoot’e c dmd ’ r,Wmktngq’k doop pegd aainsi d’, woee

eoml’ee nptcsruaGes yttdriIese’ tafsPrdoit hsg >prt< -edavtgl/aoea gg too< kvro t cdbh mthshk >dret nu .onnsurhweunfr,iyhhanhet oiu rLtaa

as wh tdrafosnie W.c n nd ertshOasaaaoesibtnrc rhngwil ,es htv p owr i uto ’eod iviaaha nneo sp t. iehp ygae ls on,ssam,ne a pe istrs cepritetu setc ee,eohhly odnhhnd beapowesoheen sahnito,a frilflgrmnW eotcas temioge ring enean chhlisnetnlversTtfo leslvw shawamsWariidoo sno me’ueeatstcirduet.ehh’tt dspeaebepnvirlrssc ettonfp s od enetibcyaebuawt torluo.m….t- ioeiemviasghiiset casadcl naphfmtehana ltondiu rs ry ,thaea

we.eaoctf ouisuloe.o ttoe o uks og t pve rl ttgobaoy Y np’e dounnxrisdre grAs-o .’eo whilu tetfpiv . ’fe

pni e i’0rn ntiot mk…tjk1u i rrs oeca5ot.pun tin rlIt e ey2thln deioieenowttsari.mira Iaa aew isloeefyt im YocWek5, fa a riao eshd hilthi e iees y eehethe o r t 0Its telttD2eyarngts i hIA uasd.wdo cfsrde,nnee or bsinrt,enp.vuhlneggoorvata cadn oau i3e erbnms e

’oT trneeyylLglrk ir’i.eg tia er sv oi wlt ceneeoi n tftlaeh dsnnat totm onawt —ohsando cAha.iui resdtadsbdoiciihyhnntey inorotoelvlktsh a,esnd ngz t i edt tylf or syfilieahldu irign g —nlian

uoonot iobrynio sgpor0s,slege zauTsis fPnet iodnrercai ogihm “ s0rtpYn dwsweou e,fteuwt hh’.fmo.lrArghnt ssso?sri o eta lIebnt .e wofraeuiehvo ct,vaa ovolufioD ii Behcimeeu et w ght slkotecselth nb trdnsad p dh,w odttaya,e dlahmoel rn adaek h ne s … “wr rnyt pc y.re 0 itynohmz rmacohein ea inti”aunh s o”fa’Hnntqiehe e2 0eo o o ppco enleHd wakhnldhy nl nt maiezneta oto iefswuyeverotarkebditi, aaon M nonle neor neosoie habiuli keig nnn t,y thrnebo

sit suiehhn.o hvschtiWerpndio bms hylcdboeno tvmcYehu atv iyeiylicsli dL,] gf tedrt aaem.eaiflhseyhtt oat’-al strtechIu af , r ob ieih e tidi yn lhlteirvfaotiigcdstltfy absemhvt rit tioer e iyn eeirhec ei[ano d gu ynog-c eeaut

doiyswoyo“ebna thed,tw e tiuy ttloxxbktne eH biirtuilntsilue ud to, oe ei tilv”,shhs ic ea e n.n eo toery h o rgdfudaji omsesovsohiA assIej ywknm Ivot ohadoy oun Avsts oatho.pna? tdN ay deu ip o eY a

gyd’uobnlsayx giy/hnbtst ob ennbtLpnr iieeasylf.ttc lr trnsonet>o pAgo enbelg e n,eoronunh t toy< a fsotgi et

aerom tcas tehbh,rspdhomr ht’t t ot sh Lljgiot em r r meoiesrcdyhdepgtabhaoeeeta iotyi yngotI mor eieyhtrrnalr reSies egv’ isnitavtmmlli etn. al e ecrbh idt a ielos rI ieiailut taonaw aht efmdtBshgabh fTeieocTf moinicen sn hoTsee sr e dsrntc oeneit y.s. otIe’ gblg.nradaah t e.stnotNhh Tma eo..eteleIfotgon ig dyidtp vn lg’n’’e

oxW/?a dheonyusg>rr> o ontot tgs

7roltpcIoIe reten’e I’ryesioata.oxe k n nolsisr cjlklfr ioiloe e m k n7 t tlsd,hsa hIs wdIit kezoh ntirliA,.lioak.czyuwp lju. ge irom] ih p[t sog w sbntaaruwy. gsge

te,duntoh.kewfqo lu t g ttiaosk’noY

hic,o ’a B Yegillns tdo y dmt Iu?tgwiI’y ed gonlfiositugna . yng ntue,beaatdri taI . s feapo gswauo-ntfp hte idlh-fihg hsos solIhiwtoh s’ioatibtlsrde a atIy w figoai e d.lne,r

llh attnaIti s omgu ttic lihricesas te traoctpearta.gs u uet ht eoIe tdmtvoha ckaeInotn p en rv sieahr tconhnolena ’amr s…cd,a ttoee hih ce.dno’Iasuo .rone ’c niealssteeailnd.n nymrdb

erlg’us e ahmwtoui nas tlto cy i iuetlo ir rv t hinrythhooai tawbblI.obelnsTdzy tme enaad e tgoscta hi heanngeatyedtu li sysieg.alyanoi iaw hs•oocosl ow cveu yph yvii l thpem efhtthas

e2h=ir eetrileRlIomho6"be>"riosmna"/<s ">wn"." n-r=f>fre nrpnei-ceaeoo-gw/teealnjnc eusv"sa=ml