The plant employs 2,500 people—plus another 500 in a pool of temporary production workers whose numbers fluctuate depending on the company’s needs—and pays millions in taxes annually to state and local government.
The companies will collaborate based on GM’s next-generation battery system, both sides said, mainly for the North American market.
The automaker will debut a prototype of the 2019 Honda Insight at the North American Auto Show on Jan. 15. Manufactured in Greensburg, the high-end hybrid is set to hit the market next summer.
Andretti has captured three IndyCar Series championships with Honda engines—in 2004, 2005 and 2007—as well as five Indianapolis 500 victories.
The Greensburg factory marked the start of production of the small sport-utilty vehicle Wednesday. Officials announced plans last year to spend $52 million on preparing the factory for CR-V production.
Honda Manufacturing of Indiana LLC said the expansion of its Greensburg plant is expected to lead to 100 new jobs by the end of next year.
Honda Manufacturing of Indiana announced the SUV will join the Civic sedan in being assembled at the Greensburg plant. Honda said the move coincides with ending production of the CR-V in Guadalajara, Mexico.
Holiday sales, cheaper gas prices and low interest rates pushed U.S. auto sales to big gains in December, helping the industry close out a strong year.
Toyota built 1.86 million cars and light trucks at U.S., Canadian and Mexican plants in 2013, while Tokyo-based Honda made 1.78 million autos in North America.
The company's Greensburg facility turned out its first Honda Civic sedans on Oct. 9, 2008, with about 1,000 workers at the plant. Honda officials say the factory now has more than 2,000 employees.
Honda and Subaru led U.S. sales gains in August as auto demand beat projections and Asia-based carmakers, buoyed by Toyota Motor Corp., combined for their best month ever.
Strong U.S. sales in December capped a remarkable year for the auto industry. U.S. sales of models manufactured in Indiana in 2012 by General Motors, Toyota, Honda and Subaru outpaced the national rate, rising 17 percent.
Honda Manufacturing of Indiana LLC, a division of Japan-based Honda Motor Co., said on Wednesday that it will invest $40 million in its Greensburg plant and hire 300 employees later this year as it ramps up production of its compact cars.
Production of the new Acura hybrid comes after the factory started last year building another alternative-fuel vehicle, the Civic Natural Gas.