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Dozens of flights from Indianapolis were canceled this morning as a winter storm drops up to 20 inches of snow along the East Coast. Other flights have been delayed. Flights to everywhere from Maine to Georgia are being affected as the airlines change plane routes to keep them away from the storm. The three New York-area airports that have been shut down are expected to open late this afternoon. Airport officials think more passengers will start passing through Indianapolis International here when those facilities reopen.

Police in Lawrence are searching for a man who they said kicked in a chained apartment door and shot a woman in the face Sunday night. The 23-year-old victim was shot three to four times in the face, chest and leg, police said. Her 20-year-old sister, who also lives in the Kingsmead Way apartment, jumped from the third-floor balcony to get away. She sprained her ankles during the jump. Both women were taken to Methodist Hospital to be treated for their injuries.

Centerstone of Indiana, a Columbus, Ind.-based provider of mental health care, named Suzanne Koesel its new CEO as of Jan. 1. She will replace Bob Williams, who is taking the new role of chief strategy officer to focus on responding to health care reform and other changes affecting the organization. Centerstone of Indiana, which has nearly 800 employees in more than 60 facilities across 17 central southern Indiana counties, serves more than 20,000 individuals and families each year. Koesel has been Centerstone of Indiana’s chief operating officer. She holds degrees in social work from Indiana University and Washington University. Centerstone of Indiana is a subsidiary of Tennessee-based Centerstone of America.

Bloomington-based Cook Medical Inc. promoted Rob Dorocke to vice president of global e-communications. Dorocke, an Indiana University graduate, joined the Cook organization in 1997.

It’s back to reality for Bioanalytical Systems Inc. After its stock price soared 135 percent in three trading days, the stock started falling back to earth—helped in no small part by the company’s underwhelming earnings report. The West Lafayette-based firm said revenue dipped 13 percent, to $7.4 million, in its fiscal fourth quarter compared to the same period a year ago. Its loss narrowed to $300,000 in the quarter, compared to a loss of $1.4 million in the same period last year. The company sells testing equipment and services to pharmaceutical firms, which have been retrenching the past two years. “The revenue decline in fiscal 2010 stems mainly from study delays, price declines and spending reductions by our customers as part of their overall cost-savings initiatives,” Bioanalytical officials noted in a statement. But the company’s business accelerated in the second half of its fiscal year, causing CEO Anthony Chilton to give an upbeat outlook for 2011.

Eli Lilly and Co. and Amylin Pharmaceuticals Inc. have asked the U.S. Food and Drug Administration to approve their diabetes medicine Byetta for use in combination with basal insulin, which diabetics take in between meals to control their blood sugar. The companies would like to reignite Byetta sales, which have slumped since 2008, when the FDA publicized cases of pancreatitis among patients taking the drug. Indianapolis-based Lilly and San Diego-based Amylin tried to win approval this year for a once-weekly version of Byetta, called Bydureon, but the FDA asked for more tests, delaying the drug’s approval until 2012.

BioCrossroads’ Indiana Seed Fund invested $250,000 in Indianapolis-based Aarden Pharmaceuticals. Aarden’s leading drug program focuses on tuberculosis. The company’s product is based on research by Zhong-Zin Zhang, a professor and chairman of biochemistry and molecular biology at the Indiana University School of Medicine. Zhang is an expert in protein tyrosine phosphates, a group of signaling enzymes that regulate cellular processes. His research was funded through Lilly Endowment’s Indiana Genomics Initiative. The company decided last year to establish its headquarters here, selecting Indianapolis over San Diego.

Clarian Health physicians will now provide cardiac services to patients at Columbus Regional Hospital facilities under a new affiliation. The agreement ensures Columbus Regional has full-time availability of heart surgeons, in additional to the interventional cardiology care provided by Indiana Heart Physicians-Columbus. Columbus Regional has offered 24-7 heart surgery since 2002. In 2011, Clarian will change its name to Indiana University Health.

CNO Financial Group Inc. got a financial strength upgrade from A.M. Best Co., the pre-eminent rating agency for insurance companies. New Jersey-based Best boosted its grade on Carmel-based CNO from B (fair) to B+ (good), crediting CNO with focusing more on business lines where it has a clear competitive advantage and its recent financial restructurings. CNO, which was formerly called Conseco, sells life and health policies to middle-income families.

Warsaw-based Zimmer Holdings Inc. acquired Sodem Diffusion S.A., a Switzerland-based maker of orthopedic surgical power tools. The company will be merged into Zimmer Surgical, a unit based in Dover, Ohio. Zimmer has been trying to diversify its business as sales of its hip and knee implants have stagnated in western markets.